1346672-96-5

Basic information

• Product Name: 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one
• Synonyms: 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one;EOS-60699
• CAS NO: 1346672-96-5
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.24166
• EINECS: -0
• Mol File: 1346672-96-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one(1346672-96-5)
• EPA Substance Registry System: 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one(1346672-96-5)

Safety Data

• Hazardous Substances Data: 1346672-96-5(Hazardous Substances Data)

Upstream product

• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 157634-02-1 tert-butyl 2-formylpiperidine-1-carboxylate 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 
• 1159825-30-5 piperidine-2-carbaldehyde hydrochloride 
• 16959-62-9 methyl indolizine-2-carboxylate 
• 118488-74-7 2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester 
• 1121-60-4 pyridine-2-carbaldehyde 
• 1346672-95-4 methyl 3-(2-aminoethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylate hydrogen chloride salt 
• 1346672-94-3 methyl 3-(cyanomethyl)-5,6,7,8-tetrahydroindolizine-2-carboxylate 
• 87281-44-5 methyl 5,6,7,8-tetrahydroindolizine-2-carboxylate 
• 16959-59-4 5,6,7,8-tetrahydroindolizine-2-carboxylic acid 

Downstream Products

• 1346672-97-6 2-bromo-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-2(1H)-yl)benzyl acetate 
• 1346672-98-7 2-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-2(1H)-yl)-6-(4-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 1346669-67-7 2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridin-3-yl)phenyl)-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one 
• 1433824-25-9 2-bromo-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]-indolizin-2(1H)-yl)benzyl acetate 
• 1433824-29-3 4-fluoro-2-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 1433824-32-8 4-fluoro-2-(6-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenylamino)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-2-yl)-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-2(1H)-yl)benzyl acetate 
• 1433820-64-4 2-[5-fluoro-2-(hydroxymethyl)-3-[6-[4-[4-(oxetan-3-yl)piperazin-1-yl]anilino]-9H-purin-2-yl]phenyl]-3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1-one 

Relevant articles and documents

Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds

An expedient single-step synthesis of 5,6,7,8-tetrahydroindolizines has been achieved via the annulation of commercially available 2-formylpiperidine hydrochloride and 1,3-dicarbonyl compounds in THF in the presence of pyrrolidine and 4 ? molecular sieves

HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

ALKYLATED PIPERAZINE COMPOUNDS

Alkylated piperazine compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.