1346870-65-2Relevant academic research and scientific papers
Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships
Krawczyk, S?ren,Otto, Monika,Otto, Alexander,Coburger, Claudius,Krug, Martin,Seifert, Marianne,Tell, Volkmar,Molnár, Joséf,Higeroth, Andreas
, p. 6309 - 6315 (2012/01/13)
A novel facile synthesis led to pyridine-2-one target structures of which first series with varying substituents have been yielded and biologically characterized as novel multidrug resistance (MDR) modulators inhibiting P-glycoprotein (P-gp). Structure-ac
