74124-17-7

Upstream product

• 100-39-0 benzyl bromide 
• 20577-27-9 pyrid-2-one-3-carbonitrile 
• 7254-34-4 2-methoxy-3-cyanopyridine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 1346870-69-6 1-benzyl-3-cyano-4-(2-methylphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-65-2 1,4-dibenzyl-3-cyano-2-oxo-1,2-dihydropyridine 
• 1346870-72-1 1-benzyl-3-cyano-4-(2-methoxyphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-63-0 1-benzyl-3-cyano-4-phenyl-2-oxo-1,2-dihydropyridine 
• 1346870-73-2 1-benzyl-3-cyano-4-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-70-9 1-benzyl-3-cyano-4-(4-methylphenyl)-2-oxo-1,2-dihydropyridine 

Relevant academic research and scientific papers

Mild and Regioselective N-Alkylation of 2-Pyridones in Water

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).

Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships

A novel facile synthesis led to pyridine-2-one target structures of which first series with varying substituents have been yielded and biologically characterized as novel multidrug resistance (MDR) modulators inhibiting P-glycoprotein (P-gp). Structure-ac