74124-17-7Relevant academic research and scientific papers
Mild and Regioselective N-Alkylation of 2-Pyridones in Water
Hao, Xin,Xu, Zhongmiao,Lu, Hongfu,Dai, Xuedong,Yang, Ting,Lin, Xichen,Ren, Feng
, p. 3382 - 3385 (2015)
A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed. Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting materials, which leads to enhanced reaction rates. The protocol demonstrated a wide substrate scope with good isolated yields (40-94%) for all of the 24 examples evaluated. High regioselectivity favoring N-alkylation over O-alkylation was observed for benzyl halides (>5:1), primary alkyl halides (>6:1), and bulky and less reactive secondary alkyl halides (>2.4:1).
Discovery of pyridine-2-ones as novel class of multidrug resistance (MDR) modulators: First structure-activity relationships
Krawczyk, S?ren,Otto, Monika,Otto, Alexander,Coburger, Claudius,Krug, Martin,Seifert, Marianne,Tell, Volkmar,Molnár, Joséf,Higeroth, Andreas
experimental part, p. 6309 - 6315 (2012/01/13)
A novel facile synthesis led to pyridine-2-one target structures of which first series with varying substituents have been yielded and biologically characterized as novel multidrug resistance (MDR) modulators inhibiting P-glycoprotein (P-gp). Structure-ac
