7254-34-4

Basic information

• Product Name: 3-CYANO-2-METHOXYPYRIDINE
• Synonyms: 2-METHOXY-3-PYRIDINECARBONITRILE;2-METHOXYNICOTINONITRILE;3-CYANO-2-METHOXYPYRIDINE;3-Cyano-2-methoxypyridine 98%;Nsc73298;2-methoxynicotinonitrile(SALTDATA: FREE);2-Methoxynicotinonitrile 98%;3-Cyano-2-Methoxypyridine, 97+%
• CAS NO: 7254-34-4
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Product Categories: blocks;Carboxes;Pyridines;CHIRAL CHEMICALS
• Mol File: 7254-34-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 58-62
• Boiling Point: 241 °C at 760 mmHg
• Flash Point: 99.6 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 0.0367mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Keep Cold
• PKA: -0.05±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-CYANO-2-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CYANO-2-METHOXYPYRIDINE(7254-34-4)
• EPA Substance Registry System: 3-CYANO-2-METHOXYPYRIDINE(7254-34-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 7254-34-4(Hazardous Substances Data)

Usage

Uses

3-Cyano-2-methoxypyridine is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C7H6N2O/c1-10-7-6(5-8)3-2-4-9-7/h2-4H,1H3

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 18356-02-0 methyl sodium 
• 75-05-8 acetonitrile 
• 163105-90-6 2-methoxypyridin-3-yl-boronic acid 
• 67-56-1 methanol 
• 52505-45-0 2-mercaptopyridine-3-carbonitrile 
• 124-41-4 sodium methylate 
• 145325-29-7 2-allylsuphanyl-3-cyanopyridine 

Downstream Products

• 7145-28-0 2-methoxy-3-pyridinecarboxamide 
• 1346870-63-0 1-benzyl-3-cyano-4-phenyl-2-oxo-1,2-dihydropyridine 
• 1346870-65-2 1,4-dibenzyl-3-cyano-2-oxo-1,2-dihydropyridine 
• 1346870-69-6 1-benzyl-3-cyano-4-(2-methylphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-70-9 1-benzyl-3-cyano-4-(4-methylphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-72-1 1-benzyl-3-cyano-4-(2-methoxyphenyl)-2-oxo-1,2-dihydropyridine 
• 1346870-73-2 1-benzyl-3-cyano-4-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine 
• 74124-17-7 1-benzyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 1446002-31-8 5-iodo-2-methoxy-nicotinonitrile 
• 1392150-47-8 5-(3,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-amine 
• 941294-54-8 5-bromo-2-methoxypyridine-3-carbonitrile 

Relevant articles and documents

Uses for whitening material of 4-(4-methylpiperazin-1-yl)-N-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)benzamide derivatives, or pharmaceutical acceptable salt thereof

The present invention relates to uses for a whitening material of a 4-(4-methylpiperazin-1-yl)-N-(5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)benzamide derivative, or a pharmaceutically acceptable salt thereof. A composition for whitening provided in

Cu-Catalyzed Cyanation of Arylboronic Acids with Acetonitrile: A Dual Role of TEMPO

The cyanation of arylboronic acids by using acetonitrile as the "CN" source has been achieved under a Cu(cat.)/TEMPO system (TEMPO=2,2,6,6-tetramethylpiperidine N-oxide). The broad substrate scope includes a variety of electron-rich and electron-poor arylboronic acids, which react well to give the cyanated products in high to excellent yields. Mechanistic studies reveal that TEMPO-CH2CN, generated in situ, is an active cyanating reagent, and shows high reactivity for the formation of the CN- moiety. Moreover, TEMPO acts as a cheap oxidant to enable the reaction to be catalytic in copper. The cyanation of arylboronic acids by using acetonitrile as the "CN" source has been achieved under a Cu(cat.)/TEMPO system. Electron-rich and electron-poor arylboronic acids react well to give the cyanated products in high to excellent yields. Mechanistic studies reveal that TEMPO-CH2CN, generated in situ, is an active cyanating reagent. Moreover, TEMPO, a cheap oxidant, enables the reaction to be catalytic in copper (see scheme; TEMPO=2,2,6,6-tetramethylpiperidine N-oxide).

DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING PAIN

The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; for use in the treatment of pain.