1347047-03-3Relevant academic research and scientific papers
The Role of Trichloroacetimidate to Enable Iridium-Catalyzed Regio- And Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study
Sorlin, Alexandre M.,Mixdorf, Jason C.,Rotella, Madeline E.,Martin, Robert T.,Gutierrez, Osvaldo,Nguyen, Hien M.
, p. 14843 - 14852 (2019)
Asymmetric allylic fluorination has proven to be a robust and efficient methodology with potential applications for the development of pharmaceuticals and practical synthesis for 18F-radiolabeling. A combined computational (dispersion-corrected
Iridium-catalyzed allylic fluorination of trichloroacetimidates
Topczewski, Joseph J.,Tewson, Timothy J.,Nguyen, Hien M.
, p. 19318 - 19321 (2012/01/06)
A rapid allylic fluorination method utilizing trichloroacetimidates in conjunction with an iridium catalyst has been developed. The reaction is conducted at room temperature under ambient air and relies on Et 3N?3HF reagent to provide branched allylic fluorides with complete regioselectivity. This high-yielding reaction can be conducted on a multigram scale and shows considerable functional group tolerance. The use of [18F]KF?Kryptofix allowed 18F- incorporation in 10 min.
