134746-26-2

Upstream product

• 134746-23-9 ethyl 2-(((benzyloxy)carbonyl)amino)-2-chloroacetate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 134746-24-0 ethyl (S,R)-N-benzyloxycarbonyl-N'-(β-phenethyl)-α,α-diaminoacetate 
• 814-68-6 acryloyl chloride 

Downstream Products

• 149253-60-1 ethyl (1'S,2R,5R)-1-benzyloxycarbonyl-3-(1'-phenyl-1'-ethyl)-5-(3-ethoxycarbonylpropyl)imidazolidin-4-one-2-carboxylate 
• 149229-39-0 ethyl (1'S,2R,5R)-1-benzyloxycarbonyl-3-(1'-phenyl-1'-ethyl)-5-(3-cyanopropyl)imidazolidin-4-one-2-carboxylate 
• 134746-28-4 (2R,5R)-5-Methyl-4-oxo-3-((S)-1-phenyl-ethyl)-imidazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF ENANTIOMERICALLY PURE D-α-AMINOADIPIC ACID

The diastereoselective cyclization of amidal (S,R)-2a, promoted by Hg(OTFA)2, afforded the imidazolidin-4-one (1'S,2R,5R)-3a as a single diastereoisomer. The subsequent transformation of the carbon-mercury bond and the acid hydrolysis of the heterocycle gave enantiomerically pure D-α-aminoadipic acid.

1,3-Asymmetric induction: Highly enantioselective synthesis of α-amino acids via 2,5-trans disubstituted imidazolidin-4-ones

2,5-Trans imidazolidin-4-ones have been obtained from mercury promoted cyclisation of unsaturated amidals containing a stereogenic centre. A new enantioselective synthesis of α-amino acids has been devised.