134816-22-1

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 134816-21-0 (5S)-1-((2S)-2-hydroxy-isovaleryl)-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 142350-56-9 (S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one 
• 134816-26-5 O-t-butyldimethylsilyl-(S)-Hiva-(S)-Phe-OMe 
• 134816-27-6 N-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-L-phenylalanine 
• 134816-19-6 (S)-Hiva-(S)-Phe-OMe 
• 142350-60-5 (S)-2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-butyrylamino]-3-phenyl-propionic acid benzyl ester 
• 142350-55-8 benzyl N-<(2S)-2-hydroxy-isovaleryl>-L-phenylalaninate 
• 134816-20-9 (5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 

Downstream Products

• 160811-56-3 (S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 160811-55-2 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 205498-70-0 C₅₀H₇₁N₅O₁₁ 
• 205498-68-6 (S)-1-{(3R,4S,5S)-4-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-methyl-amino]-3-methoxy-5-methyl-heptanoyl}-pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 1053738-42-3 (S)-1-{(3R,4S,5S)-4-[((S)-2-Amino-3-methyl-butyryl)-methyl-amino]-3-methoxy-5-methyl-heptanoyl}-pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 123884-00-4 dolastatin 15 
• 160811-53-0 (S)-Pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 123884-00-4 (-)-dolastatin 15 

Relevant academic research and scientific papers

Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid

Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull

Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15

The natural cytotoxic compounds dolastatins 10 and 15 exhibit great similarities in structure and in their biological activity profiles. Two compounds (1 and 2) formed by interchanging the dolaisoleuine residue of dolastatin 10 and the MeVal-Pro dipeptide

The Dolastatins 20. Convenient Synthetic Route to Dolastatin 15

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3