134816-20-9

Upstream product

• 67-56-1 methanol 
• 134816-27-6 N-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-L-phenylalanine 
• 182573-16-6 (S)-N-[(S)-1-Benzyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-2-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyramide 
• 142350-55-8 benzyl N-<(2S)-2-hydroxy-isovaleryl>-L-phenylalaninate 
• 962-39-0 L-Phenylalanine benzyl ester 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 142350-56-9 (S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 134816-26-5 O-t-butyldimethylsilyl-(S)-Hiva-(S)-Phe-OMe 
• 134816-19-6 (S)-Hiva-(S)-Phe-OMe 
• 142350-60-5 (S)-2-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-butyrylamino]-3-phenyl-propionic acid benzyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 160811-53-0 (S)-Pyrrolidine-2-carboxylic acid (S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl ester 
• 160811-56-3 (S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 160811-55-2 Z-(S)-Val-NMe-(S)-Val-(S)-Pro-(S)-Pro-(S)-Hiva-(S)-Dpy 
• 142350-59-2 (5S)-1-<(2S)-O-<-L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolyl>-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 123884-00-4 (-)-dolastatin 15 
• 134816-21-0 (5S)-1-((2S)-2-hydroxy-isovaleryl)-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 123884-00-4 dolastatin 15 
• 134816-22-1 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[(S)-1-((S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-pyrrole-1-carbonyl)-2-methyl-propyl] ester 1-tert-butyl ester 

Relevant academic research and scientific papers

Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid

Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull

The Dolastatins 20. Convenient Synthetic Route to Dolastatin 15

A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3

Total Synthesis of the Proposed Structure of Dolastatin 15

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit