135040-87-8Relevant academic research and scientific papers
A new synthesis of the benzofuran adenosine antagonist XH-14
Hutchinson, Sally A.,Luetjens, Henning,Scammells, Peter J.
, p. 3081 - 3084 (2007/10/03)
5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzo[b]furan-3 -carbaldehyde (XH-14, 1) has been reported to be a potent A1 adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.
Regioselective Introduction of Carbon-3 Substituents to 5-Alkyl-7-methoxy-2-phenylbenzofurans: Synthesis of a Novel Adenosine A1 Receptor Ligand and Its Derivatives
Yang, Zhen,Liu, Han Biao,Lee, Chi Ming,Chang, Hson Mou,Wong, Henry N. C.
, p. 7248 - 7257 (2007/10/02)
By maintaining the balance between the electronic requirements, the stereochemical restrictions as well as the kinetic and thermodynamic factors, the unprecedented regioselective electrophilic aromatic substitution of formyl and nitro groups to carbon-3 o
Naturally Occurring Benzofuran: Isolation, Structure Elucidation and Total Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde, a Novel Adenosine A1 Receptor Ligand Isolated from Salvia miltior
Yang, Zhen,Hon, Po Ming,Chui, Kuk Ying,Xu, Zun Le,Chang, Hson Mou,et al.
, p. 2061 - 2064 (2007/10/02)
A naturally occurring benzofuran, namely 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde was isolated from the roots of S. miltiorrhiza Bunge "Danshen".Its structure was established by means of spectroscopic metho
