135137-86-9

Upstream product

• 135137-85-8 1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-amino-1-tert-butyldimethylsilylhexan-1-ol 
• 4048-33-3 6-amino-1-hexanol 
• 58-85-5 biotin 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 144095-63-6 N¹-4,4'-dimethoxytrityl-(+)-biotin 
• 124884-00-0 Biotinyl-6-amino-1-tert-butyldimethylsilylhexan-1-ol 
• 4443-68-9 biotin 
• 124883-99-4 6-((tert-butyldimethylsilyl)oxy)hexan-1-amine 

Downstream Products

• 135137-87-0 C₄₆H₆₄N₅O₆PS 

Relevant academic research and scientific papers

Long-chain biotin marker and preparation method and application thereof

The invention discloses a long-chain biotin marker and a preparation method and application thereof. The long-chain biotin marker comprises a biotin molecule, a spacer arm and a reaction group. The biotin molecule comprises a ring structure and a valeric acid side chain, a structure formula (I) of the spacer arm is as shown in the specification, a structural formula (II) of the reaction group is as shown in the specification, the valeric acid side chain in the biotin molecule is connected with NH at a first tail end of the spacer arm, oxygen at a second tail end of the spacer arm is combined with phosphorus in the reaction group to form an O-P bond, and accordingly connection between the spacer arm and the reaction group is realized. The long-chain biotin marker is used for gene capturingand sequencing.

A LONG CHAIN BIOTIN PHOSPHORAMIDITE REAGENT FOR THE AUTOMATED SYNTHESIS OF 5'-BIOTINYLATED OLIGONUCLEOTIDES

An N-dimethoxytritylated biotin group coupled to a 6-aminohexanol linker was converted into a phosphoramidite to yield a biotinylating reagent which can be used in automated solid-phase synthesis to produce 5'-biotinylated oligonucleotides in high yields.