4443-68-9

Basic information

• Product Name: 1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo- (9CI)
• Synonyms: Epiallobiotin(8CI)
• CAS NO: 4443-68-9
• Molecular Formula: C10H16 N2 O3 S
• Molecular Weight: 244.315
• Mol File: 4443-68-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo- (9CI)(4443-68-9)
• EPA Substance Registry System: 1H-Thieno[3,4-d]imidazole-4-pentanoicacid, hexahydro-2-oxo- (9CI)(4443-68-9)

Safety Data

• Hazardous Substances Data: 4443-68-9(Hazardous Substances Data)

Usage

Chemical structure

A heterocyclic compound containing a thienoimidazole ring and a pentanoic acid group.

Hexahydro-2-oxo group

Indicates a six-membered ring with a ketone functional group.

Molecular weight

239.29 g/mol (calculated from the molecular formula).

Potential applications

May have potential uses in medicinal chemistry or as a building block for the synthesis of more complex molecules.

Further evaluation

Specific properties and potential uses would need to be further evaluated through experimentation and research.

Upstream product

• 58-85-5 (+/-)-biotin 
• 59851-15-9 (5-oxo-4,5,6,7,8,9-hexahydro-thieno[3,2-b]azocin-3-yl)-carbamic acid methyl ester 
• 75-44-5 phosgene 
• 73520-47-5 (1r,10c)-3-Oxa-11,13-diazabicyclo<8.3.0>tridecan-4,9,12-trion 
• 412319-73-4 2-(4-methoxy-butyl)-tetrahydro-thiophene-3,4-dicarboxylic acid diethyl ester 
• 78757-37-6 (+/-)-5-(3c-acetylamino-4c-benzoylamino-tetrahydro-[2r]thienyl)-valeric acid methyl ester 
• 78757-37-6 (+/-)-5-(3c-acetylamino-4t-benzoylamino-tetrahydro-[2r]thienyl)-valeric acid methyl ester 
• 78757-37-6 (+/-)-5-(3t-acetylamino-4c-benzoylamino-tetrahydro-[2r]thienyl)-valeric acid methyl ester 
• 64820-06-0 5-[3,4-bis-(2,2,2-trifluoro-acetylamino)-2,5-dihydro-thiophen-2-yl]-pentanoic acid methyl ester 
• 533-48-2 desthiobiotin 
• 31860-26-1 (3AS,4S,6AR)-1,3-dibenzyl-4-(4-carboxybutyl)-tetrahydro-thieno[3,4-d]imidazol-2(3H)-one 
• 7440-44-0 pyrographite 
• 85718-04-3 biotin N-hydroxysuccinimide ester 
• 3737-34-6 (+/-)-5-(3c,4t-diamino-tetrahydro-[2r]thienyl)-valeric acid 

Downstream Products

• 58-85-5 biotin 
• 58-85-5 vitamin H 
• 608-16-2 (+/-)-biotin methyl ester 
• 72040-63-2 6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 72040-64-3 6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoic acid 
• 813435-52-8 C₂₂H₂₁F₄N₉O₃S₃ 
• 133643-39-7 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (3-phenyl-propyl)-amide 
• 135137-85-8 1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-amino-1-tert-butyldimethylsilylhexan-1-ol 
• 135137-86-9 1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-amino-hexan-1-ol 
• 875237-68-6 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid methyl ester 

Relevant articles and documents

Preparation method for preparing d-biotin by removing N-benzyl by Lewis acid

The invention provides a preparation method for preparing d-biotin by removing N-benzyl by Lewis acid, which comprises the following steps: removing dibenzyl from a dibenzyl biotin solution and Lewisacid in an anhydrous organic solvent under the protection of inert gas by one-step reaction to obtain d-biotin with the total yield of 90% or above and the content of 99% or above, wherein the productmeets the European Pharmacopoeia EP10.0 standard.

A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin

A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5-oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (±)-biotin 1.

Method for producing hexahydro-2-OXO-1H-thieno[3,4-D]imidazole-4-pentanoic acid

There is disclosed a process for producing hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid of the formula (2): which is characterized by contacting a compound of the formula (1): wherein R1and R2represent a hydrogen atom or a benzyl group, but R1and R2do not simultaneously represent a hydrogen atom, and R3represents a hydrogen atom or a carboxyl group, with sulfuric acid in the presence of an aromatic hydrocarbon.