176961-50-5

Basic information

• Product Name: 2-(4-BROMO-PHENYL)-OXAZOLE
• Synonyms: 2-(4-bromophenyl)-1,3-oxazole;Oxazole, 2-(4-broMophenyl)-;2-(4-BROMO-PHENYL)-OXAZOLE
• CAS NO: 176961-50-5
• Molecular Formula: C₉H₆BrNO
• Molecular Weight: 224.05
• Mol File: 176961-50-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 296.613 °C at 760 mmHg
• Flash Point: 133.187 °C
• Appearance: /
• Density: 1.525 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-BROMO-PHENYL)-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMO-PHENYL)-OXAZOLE(176961-50-5)
• EPA Substance Registry System: 2-(4-BROMO-PHENYL)-OXAZOLE(176961-50-5)

Safety Data

• Hazardous Substances Data: 176961-50-5(Hazardous Substances Data)

Usage

General Description

2-(4-Bromo-phenyl)-oxazole is a chemical compound with the molecular formula C9H6BrNO. It is a heterocyclic aromatic organic compound that contains a five-membered oxazole ring with a bromo-substituted phenyl group attached. 2-(4-BROMO-PHENYL)-OXAZOLE is commonly used in pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. It is also used as a reagent in organic synthesis for the formation of new carbon-carbon bonds. Additionally, 2-(4-Bromo-phenyl)-oxazole is known for its potential antimicrobial and anti-inflammatory properties, making it a valuable research tool for medicinal chemistry studies.

Upstream product

• 288-36-8 1,2,3-triazole 
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• 872-36-6 vinylene carbonate 
• 698-67-9 p-bromobenzamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 189120-01-2 2-(4-bromo-phenyl)-4,5-dihydro-oxazole 
• 22483-09-6 2,2-dimethoxyethylamine 
• 13518-80-4 2-trimethylsilyl-2H-1,2,3-triazole 

Downstream Products

• 845616-98-0 tert-butyl 4-(4-(oxazol-2-yl)phenyl)piperazine-1-carboxylate 
• 220697-59-6 2-(4-(piperazin-1-yl)phenyl)oxazole 
• 1428536-39-3 2-(4-(4-(thiophen-2-ylmethyl)piperazin-1-yl)phenyl)oxazole 
• 1428536-38-2 2-(4-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl)phenyl)oxazole 
• 1428536-37-1 2-(4-(4-(pyridin-3-ylmethyl)piperazin-1-yl)phenyl)oxazole 
• 1402636-54-7 (2R)-2-methyl-2-(methylsulfonyl)-4-{4-[4-(1,3-oxazol-2-yl)phenyl]-1H-pyrazol-1-yl}butanoic acid 
• 1402636-55-8 (2R)-2-methyl-2-(methylsulfonyl)-4-{4-[4-(1,3-oxazol-2-yl)phenyl]-1H-pyrazol-1-yl}-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1402636-53-6 (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4-[4-(1,3-oxazol-2-yl)phenyl]-1Hpyrazol-1-yl}butanamide 
• 501944-79-2 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3-oxazole 
• 176960-47-7 N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 176961-14-1 N-(3,4-dimethyl-5-isoxazolyl)-N-[(methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 

Relevant articles and documents

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS

The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Preparation of 2-substituted oxazoles

A simple and economical method for 2-substituted oxazole synthesis and its scope are described.