135181-98-5

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 103-67-3 benzyl-methyl-amine 
• 100-52-7 benzaldehyde 
• 74-89-5 methylamine 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 135182-06-8 4-(4-Methoxy-phenyl)-2-methyl-1,4-dihydro-2H-isoquinolin-3-one 

Relevant academic research and scientific papers

Catalytic chemical amide synthesis at room temperature: One more step toward peptide synthesis

An efficient method has been developed for direct amide bond synthesis between carboxylic acids and amines via (2-(thiophen-2-ylmethyl)phenyl)boronic acid as a highly active bench-stable catalyst. This catalyst was found to be very effective at room temperature for a large range of substrates with slightly higher temperatures required for challenging ones. This methodology can be applied to aliphatic, α-hydroxyl, aromatic, and heteroaromatic acids as well as primary, secondary, heterocyclic, and even functionalized amines. Notably, N-Boc-protected amino acids were successfully coupled in good yields with very little racemization. An example of catalytic dipeptide synthesis is reported.

Synthesis of 4-aryl-1,4-dihydro-3(2H)-isoquinolinones by oxidative cyclization of N-benzylaraylacetamides

4-Aryl-1,4-dihydro-3(2H)-isoquinolinones are obtained by oxidative cyclization of N-benzyl-N-alkylarylacetamides with lead tetraacetate in acetic acid/trifluoroacetic acid.