1351927-00-8 Usage
General Description
T338C Src-IN-2 is a selective and potent inhibitor of the tyrosine kinase enzyme Src, which plays a critical role in signal transduction pathways and is often overexpressed in cancer cells. The chemical has been designed to specifically inhibit the activity of the T338C mutant form of Src, which is often associated with drug resistance in cancer. T338C Src-IN-2 has shown promising results in preclinical studies, demonstrating its ability to effectively inhibit the growth and survival of cancer cells that contain the T338C mutation. This makes it a potential candidate for the development of targeted cancer therapies for patients with this specific genetic mutation.
Check Digit Verification of cas no
The CAS Registry Mumber 1351927-00-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,1,9,2 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1351927-00:
(9*1)+(8*3)+(7*5)+(6*1)+(5*9)+(4*2)+(3*7)+(2*0)+(1*0)=148
148 % 10 = 8
So 1351927-00-8 is a valid CAS Registry Number.
1351927-00-8Relevant articles and documents
METHODS AND COMPOSITIONS FOR KINASE INHIBITION
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Paragraph 0360; 0361, (2013/06/05)
The present invention sets forth a new chemical genetic approach for engineering kinase enzymes with a cysteine gatekeeper residue as well as for developing electrophilic inhibitors thereto. The present invention also provides a Src proto-oncogenic tyrosine kinase with a cysteine gatekeeper that recapitulates wild type activity and can be irreversibly inhibited both in vitro and in cells. The present invention also provides methods and compositions for modulating kinases and for treating kinase-associated diseases.
