1351987-25-1

Basic information

• Product Name: (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate
• Synonyms: (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate
• CAS NO: 1351987-25-1
• Molecular Weight: 389.448
• Mol File: 1351987-25-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate(1351987-25-1)
• EPA Substance Registry System: (S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate(1351987-25-1)

Safety Data

• Hazardous Substances Data: 1351987-25-1(Hazardous Substances Data)

Upstream product

• 1351987-24-0 (S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid 
• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 
• 63-91-2 L-phenylalanine 
• 6148-64-7 ethyl potassium malonate 
• 1351987-23-9 (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate 
• 134807-37-7 (4S)-3-((2S)-4-(tert-butoxy)-2-(1-methylethyl)-4-oxobutanoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one 
• 108-12-3 isopentanoyl chloride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 145589-03-3 (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one 

Downstream Products

• 1351987-29-5 (S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate 
• 1351987-30-8 (5S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methyl-3-oxoheptanoate 
• 1351987-31-9 (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate 

Relevant articles and documents

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.

PROCESS FOR PRODUCING ALISKIREN

A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.