135133-23-2

Usage

Uses

Used in Pharmaceutical Industry:
(2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol is used as an impurity in the synthesis of efinaconazole (E435070) for the pharmaceutical industry. Efinaconazole is an antifungal medication used to treat certain fungal infections, such as onychomycosis. The presence of (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as an impurity is significant for quality control and safety assessments during the drug development process.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 288-88-0 1,2,4-Triazole 
• 212890-35-2 2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane 
• 348-57-2 2,4-difluorobromobenzene 
• 144025-04-7 (2,4-difluorophenyl)magnesium bromide 
• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 
• 135267-12-8 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 127001-03-0 (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 126918-16-9 (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one 
• 41253-21-8 sodium triazole 

Downstream Products

• 1266605-73-5 (2R,3R)-2-(2,4-difluorophenyl)-3-[4-(5-fluoro-1H-indol-3-ylmethyl)-piperazin-1-yl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-75-7 C₂₅H₂₇ClF₂N₆O 
• 1266605-76-8 C₂₅H₂₇BrF₂N₆O 
• 1266605-77-9 C₂₆H₃₀F₂N₆O 
• 1266605-79-1 C₂₅H₂₇F₂N₇O₃ 
• 1266605-80-4 C₂₆H₃₀F₂N₆O₂ 
• 1266605-81-5 C₂₅H₂₇F₂N₉O 
• 1266605-82-6 C₂₆H₂₇F₂N₇O 
• 1266605-83-7 C₂₆H₂₉F₂N₇O₂ 
• 1266605-85-9 C₂₅H₂₇F₃N₆O 
• 1266605-86-0 C₂₅H₂₇ClF₂N₆O 
• 1266605-87-1 C₂₅H₂₇F₂N₉O 
• 1266606-15-8 C₂₆H₃₀F₂N₆O 
• 1266605-88-2 C₂₆H₂₇F₂N₇O 

Relevant academic research and scientific papers

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

Triazole alcohol derivative, and preparation method and application thereof

The invention relates to a triazole alcohol derivative, and a preparation method and an application thereof. The chemical structure of the triazole alcohol derivative is represented by formula I, A inthe formula I represents a benzene ring or a substituted benzene ring, and the substituent group of the substituted benzene ring can be located at each position of the benzene ring, is monosubstituted or polysubstituted, and is selected from: a) halogen which is F, Cl, Br or I; b) an electron-withdrawing group, wherein the electron withdrawing group is a cyano group, a nitro group or a trifluoromethyl group; c) a C1-4 low alkyl group or a halogen-substituted low alkyl group; and d) a C1-4 low alkoxy group or a halogen-substituted low alkoxy group. The compound has the advantages of high antifungal activity, low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal medicines.

The process development of ravuconazole: An efficient multikilogram scale preparation of an antifungal agent

The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.

Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.