135133-23-2

Basic information

• Product Name: (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• Synonyms: Efinaconazole Impurity F;Efinaconazole Impurity 39;(2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)...;(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 3-THP Ether;(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-[(1R)-1-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (αR)-;(2R,3R)-2-(2,4-difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol(WXG00770);(alphaR)-alpha-(2,4-Difluorophenyl)-alpha-[(1R)-1-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-1H-1,2,4-triazole-1-ethanol
• CAS NO: 135133-23-2
• Molecular Formula: C₁₇H₂₁F₂N₃O₃
• Molecular Weight: 353.36
• Mol File: 135133-23-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 533.9±60.0 °C(Predicted)
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 11.61±0.29(Predicted)
• CAS DataBase Reference: (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol(135133-23-2)
• EPA Substance Registry System: (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol(135133-23-2)

Safety Data

• Hazardous Substances Data: 135133-23-2(Hazardous Substances Data)

Usage

Uses

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 3-THP Ether is an impurity of efinaconazole (E435070).

Upstream product

• 348-57-2 2,4-difluorobromobenzene 
• 144025-04-7 (2,4-difluorophenyl)magnesium bromide 
• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 
• 288-88-0 1,2,4-Triazole 
• 135267-12-8 2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran 
• 110-87-2 3,4-dihydro-2H-pyran 
• 212890-35-2 2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 127001-03-0 (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 126918-16-9 (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one 
• 41253-21-8 sodium triazole 

Downstream Products

• 1266605-73-5 (2R,3R)-2-(2,4-difluorophenyl)-3-[4-(5-fluoro-1H-indol-3-ylmethyl)-piperazin-1-yl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-75-7 C₂₅H₂₇ClF₂N₆O 
• 1266605-76-8 C₂₅H₂₇BrF₂N₆O 
• 1266605-77-9 C₂₆H₃₀F₂N₆O 
• 1266605-79-1 C₂₅H₂₇F₂N₇O₃ 
• 1266605-80-4 C₂₆H₃₀F₂N₆O₂ 
• 1266605-81-5 C₂₅H₂₇F₂N₉O 
• 1266605-82-6 C₂₆H₂₇F₂N₇O 
• 1266605-83-7 C₂₆H₂₉F₂N₇O₂ 
• 1266605-85-9 C₂₅H₂₇F₃N₆O 
• 1266605-86-0 C₂₅H₂₇ClF₂N₆O 
• 1266605-87-1 C₂₅H₂₇F₂N₉O 
• 1266606-15-8 C₂₆H₃₀F₂N₆O 
• 1266605-88-2 C₂₆H₂₇F₂N₇O 

Relevant articles and documents

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

Synthesis and activity of novel indole linked triazole derivatives as antifungal agents

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Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.