13535-13-2

Basic information

• Product Name: 2-AMINO-5-PHENYLPYRAZINE
• Synonyms: 2-AMINO-5-PHENYLPYRAZINE;5-PHENYL-PYRAZIN-2-YLAMINE;2-Amino-5-phenylpyrazine552.63 $;5-phenylpyrazin-2-amine;2-Pyrazinamine, 5-phenyl-;2-Amino-5-phenylpyrazine 97%
• CAS NO: 13535-13-2
• Molecular Formula: C₁₀H₉N₃
• Molecular Weight: 171.2
• Product Categories: Chloropyrazines, etc.;Pyrazines
• Mol File: 13535-13-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 146 °C
• Boiling Point: 339.298 °C at 760 mmHg
• Flash Point: 185.644 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 9.28E-05mmHg at 25°C
• Refractive Index: 1.633
• Solubility: soluble in Methanol
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-PHENYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-PHENYLPYRAZINE(13535-13-2)
• EPA Substance Registry System: 2-AMINO-5-PHENYLPYRAZINE(13535-13-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38-43
• Safety Statements: 22-24/25-26-36/37-39-51
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13535-13-2(Hazardous Substances Data)

Usage

General Description

2-Amino-5-phenylpyrazine is a chemical compound with the molecular formula C10H9N3. It is a heterocyclic aromatic amine, which means it contains a ring structure made up of carbon and nitrogen atoms. 2-AMINO-5-PHENYLPYRAZINE is commonly used in the pharmaceutical industry as a building block in the synthesis of various pharmaceuticals and drug molecules. It has also been found to have potential applications in materials science and organic chemistry. 2-Amino-5-phenylpyrazine is a versatile compound with a range of potential uses in various industries.

InChI:InChI=1/C10H9N3/c11-10-7-12-9(6-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,13)

Upstream product

• 25844-73-9 2-Chloro-5-phenyl-pyrazine 
• 532-54-7 E-isonitrosoacetophenone 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 33332-29-5 2-amino-5-chloropyrazine 
• 98-80-6 phenylboronic acid 
• 59489-71-3 5-amino-2-bromopyrazine 
• 910791-87-6 N-[(3-bromo-5-phenyl)pyrazin-2-yl]pyridinium aminide 
• 67602-05-5 2-amino-3-bromo-5-phenylpyrazine 
• 50627-20-8 2-amino-3-cyano-5-phenylpyrazine-1-N-oxide 

Downstream Products

• 120821-78-5 (3-isopropyl-6,6-dimethyl-[1,2,4]trioxan-5-yl)-(5-phenyl-pyrazin-2-yl)-amine 
• 56888-73-4 2-methyl-6-phenylimidazo<1,2-a>pyrazin-3(7H)-one hydrochloride 
• 1195313-71-3 trans-3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 328232-42-4 trans-3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 328232-52-6 trans-3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[4-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 1195313-64-4 trans-3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[5-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 1195313-93-9 trans-3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[7-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 1242558-71-9 C₂₁H₂₁N₅O₃ 
• 1262118-04-6 2-benzyl-6-phenyl-8-phenoxyimidazo[1,2-a]pyrazin-3(7H)-one 
• 1262117-93-0 2-benzyl-6-phenyl-8-(phenylthio)imidazo[1,2-a]pyrazin-3(7H)-one 
• 25844-70-6 1-oxy-5-phenyl-pyrazin-2-ylamine 
• 1192809-20-3 N-(5-phenylpyrazin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine 

Relevant articles and documents

Efficient synthesis of a highly selective NPY-5 receptor antagonist: A drug candidate for the treatment of obesity

A concise and practical synthesis of highly selective NPY-5 receptor antagonist 1 is described. The animopyrazine intermediate 3 was synthesized via either monobromination of aminopyrazine or palladium-catalyzed regioselective debromination of dibromopyrazine followed by an efficient Suzuki-Miyaura coupling. For the preparation of the spirolactone piperidine 2, significantly improved yield was achieved by using a combination of n-BuMgCl and n-BuLi. This protocol also dramatically increased the thermal stability of the aryllithium intermediate and eliminated the requirement for costly cryogenic conditions. The union of the spirolactone piperidine 2 and aminopyrazine 3 via a carbonyl group was accomplished using phenyl chloroformate delivering the target molecule in high yield.

A novel coelenterate luciferin-based luminescent probe for selective and sensitive detection of thiophenols

The first dual bioluminescent and chemiluminescent sensor for detecting highly toxic thiophenols has been developed. Such a probe was designed by using a coelenterazine analogue as the luminophore and dinitrophenyl ether as the recognition moiety. It shou

Synthesis and chemiluminescent properties of 6,8-diaryl-2-methylimidazo[1, 2-a]pyrazin-3(7H)-ones: Systematic investigation of substituent effect at para-position of phenyl group at 8-position

6,8-Diphenylimidazopyrazinone derivatives having a substituent R (R = CF3, H, and OMe) at para position of the 8-phenyl group were synthesized and their chemiluminescent properties were investigated. The chemiluminescence maxima (CLmax/su