1353579-45-9

Upstream product

• 1353579-39-1 (S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-ethyl-4-methoxyfuro[3,4-c]pyridin-3(1H)-one 
• 1353579-41-5 (S)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(3-(hydroxymethyl)-2-methoxypyridin-4-yl)propan-1-ol 
• 1353579-43-7 4-((S)-1-(benzyloxy)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propyl)-3-((benzyloxy)methyl)-2-methoxypyridine 
• 16498-81-0 2-methoxynicotinic acid 
• 74334-84-2 (4R)-1-(2,2-dimethyl)-(1,3)dioxolan-4-ylpropan-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1201830-88-7 (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanal 
• 1201830-89-8 (S)-2-(benzyloxy)-2-(3-((benzyloxy)methyl)-2-methoxypyridin-4-yl)butanoic acid 
• 19685-09-7 (S)-10-hydroxycamptothecin 
• 19685-10-0 10-methoxycamptothecin 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 7689-03-4 camptothecin 
• 1393646-06-4 (2S,3S)-3-benzyloxy-3-(3-benzyloxymethyl-2-methoxypyridin-4-yl)-2-hydroxypentanoic acid 

Relevant academic research and scientific papers

CAMPTOTHECIN COMPOUND CONTAINING STABLE 7-MEMBERED LACTONE RING, PREPARATION METHOD AND USE

Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R1 is H, a C1～C3 alky

Total synthesis of camptothecin and SN-38

A new practical and concise total synthesis of enantiopure camptothecin and SN-38 (14% overall yield, 99.9% ee and 99.9% purity) was described, starting from inexpensive and readily available materials. The development of column chromatography-free purification was achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.