135388-59-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Pentadien-1-one, 4-methyl-1,5-diphenyl-, (E,E)is used as an intermediate in the production of various pharmaceuticals due to its versatile chemical properties and potential therapeutic effects.
Used in Medicinal Applications:
Chalcone is used as a potential anti-inflammatory, anti-cancer, and antioxidant agent for medicinal applications, owing to its biological activities and ability to modulate various signaling pathways.
Used in Cosmetic Industry:
2,4-Pentadien-1-one, 4-methyl-1,5-diphenyl-, (E,E)is used as an ingredient in cosmetic products for its potential skin health benefits, including anti-inflammatory and antioxidant properties.
Used in Natural Insecticides:
Chalcone is used as a potential natural insecticide, leveraging its bioactive properties to control pests in an environmentally friendly manner.
Used in Food Industry:
2,4-Pentadien-1-one, 4-methyl-1,5-diphenyl-, (E,E)is found in various food products such as fruits, vegetables, and beverages, contributing to their flavor, aroma, and potential health benefits.

Upstream product

• 101-39-3 2-methyl-3-phenyl-2-propenal 
• 98-86-2 acetophenone 
• 15174-47-7 α-methyl-trans-cinnamaldehyde 
• 1196-67-4 (E)-β-methylcinnamaldehyde 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 

Downstream Products

• 296759-69-8 3-benzoyl-4-(α-methylstyryl)-2-pyrazoline 
• 139435-85-1 N,N-Dimethyl-4-((1E,3E)-2-methyl-5-oxo-5-phenyl-penta-1,3-dienyl)-benzenesulfonamide 
• 139435-86-2 N,N-Diethyl-4-((1E,3E)-2-methyl-5-oxo-5-phenyl-penta-1,3-dienyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Amine-promoted synthesis of vinyl aziridines

N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of α,β,γ,δ- unsaturated carbonyl compounds. The reaction is completely regioselective (>95: 5) for the α,β-alkene and completely diastereosel

Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-MnIII as the catalyst

(E,E)-Cinnamylideneacetophenones 3a-j were epoxidized under mild conditions with Jacobsen's catalyst 4 and hydrogen peroxide or iodosylbenzene as oxidants. γ,δ-Monoepoxides and a diastereomeric mixture of α,β:γ,δ-diepoxides were obtained in each case, and

Synthesis of 3-benzoyl-4-styryl-2-pyrazolines and their oxidation to the corresponding pyrazoles

The 3-benzoyl-4-styryl-2-pyrazolines 2a-g were prepared from the regioselective 1,3-dipolar cycloaddition reactions of (E,E)- cinnamylideneacetophenones 1a-g and diazomethane. The new compounds 3-(2- benzofuranyl)-4-styryl-2-pyrazolines (5c,d) were also obtained as by-products in some cases. The oxidation of the 3-benzoyl-4-styryl-2-pyrazolines 2a-g into 3(5)-benzoyl-4-styrylpyrazoles 3a-g is also reported. Configurational and conformational features of all compounds were established by NMR spectroscopy.

Regiocontrol synthesis of β-trimetylsilyloxy carbonyl compounds through an aldolgrignard elaboration sequence

Reaction of carbonyl compounds with α-lithio- or α-halozinc N-methoxy-N-methylamides, followed by silylation and Grignard addition resulted in a regiocontrolled synthesis of β-trimethylsilyloxy carbonyl compounds.