135441-91-7Relevant academic research and scientific papers
The PMe3-catalyzed addition of enantiomerically pure (?)-MenthylO(Ph)P(O)H to electron-deficient alkenes: an efficient way for the preparation of P-stereogenic compounds
Saga, Yuta,Mino, Yuka,Kawaguchi, Shin-ichi,Han, Daoqing,Ogawa, Akiya,Han, Li-Biao
, p. 84 - 89 (2017)
A variety of P-stereogenic organophosphorus compounds can be readily prepared by stereoretentive addition. The PMe3-catalyzed addition of optically active (?)MenthylO(Ph)P(O)H compounds to electron deficient alkenes occur stereospecifically, to produce the corresponding P-stereogenic adducts in high yields. By simply removing the volatiles under vacuum, spectroscopically pure products can be obtained. The present method provides a salt-free clean process for the preparation of P-chiral organophosphorus compounds.
Stereospecific addition of H-P bond to alkenes: A simple method for the preparation of (RP)-phenylphosphinates
Han, Li-Biao,Zhao, Chang-Qiu
, p. 10121 - 10123 (2005)
A variety of functionalized optically pure (Rp)- alkylphenylphosphinates are readily prepared by stereospecific radical or base-catalyzed additions of the easily available (Rp)-menthyl phenylphosphinate to alkenes.
Sythesis of P-Chiral Compounds
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, (2014/01/08)
Shown is the preparation and subsequent elaboration of P-chiral compounds that can be used as a building block for many P-chiral ligands used, for example, in asymmetric catalytic reactions. Specifically, a synthesis is shown for RP(O)(OR*)CH2OH, with R=H, Ph, aryl, alkyl, and R*=menthol (and other chiral alcohol-derived moieties), especially HP(O)(OMen)CH2OH (Men=L-menthol). This versatile building block is easily synthesized via reaction of inexpensive starting materials, H3PO2, menthol as the chiral auxiliary, and paraformaldehyde.
