1354633-20-7Relevant articles and documents
A new efficient synthetic route for the synthesis of the antiallergic drug, olopatadine hydrochloride, via stereospecific palladium-catalyzed reaction
Nishimura, Koichiro,Kinugawa, Masahiko
, p. 225 - 231 (2012/06/05)
A new practical and efficient synthetic route for the synthesis of olopatadine hydrochloride via the intramolecular stereospecific seven-membered ring cyclization from an alkyne intermediate using palladium catalyst and hydride source was established. Furthermore, the optimization of that key stereospecific reaction was examined by design of experiment (DoE), and the desired Z-isomer could be obtained with high yield.