1354834-22-2

Upstream product

• 621-59-0 isovanillin 
• 76678-64-3 3-(3-benzyloxy-4-methoxyphenyl)acrylaldehyde 
• 162269-90-1 3-bromo-4-(methoxymethoxy)benzaldehyde 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 60553-38-0 methyl 3-(3-bromo-4-hydroxy-phenyl)propionate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 1354834-16-4 C₁₃H₁₈BrNO₄ 
• 1354834-14-2 C₁₁H₁₃BrO₄ 
• 1354834-13-1 C₁₂H₁₅BrO₄ 
• 1354834-33-5 (E)-1-(3-bromo-4-(methoxymethoxy)phenyl)-7-(3-hydroxy-4-methoxyphenyl)hept-6-en-3-one 
• 1354834-18-6 1-(3-bromo-4-(methoxymethoxy)phenyl)hept-6-en-3-one 

Downstream Products

• 1447240-90-5 C₂₇H₂₈O₄ 

Relevant academic research and scientific papers

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

The natural product engelhardione is an underexplored chemotype for developing novel treatments for bacterial infections; we therefore explored this natural product scaffold for chemical diversification and structure-activity relationship studies. Macrocy

Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling

Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling.

Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs

The macrocyclic diarylether heptanoid (MDEH) natural products have been used in folk medicine for centuries. MDEHs are reported to exert anti-tumor properties by inhibiting the activation of NF-κB. Here we report the synthesis of a small MDEH library (first reported synthesis of racemic platycarynol) using a Grubbs cross metathesis/Ullmann cyclization strategy. Evaluation of the library led to the identification of MDEH 9b which sensitizes pancreatic cancer cells to gemcitabine mediated growth inhibition and apoptosis.