135508-69-9

Upstream product

• 36919-02-5 pentafluorophenyl chloroformate 
• 29126-13-4 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 
• 908093-98-1 diazodiphenylmethane 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 5935-65-9 Desacetylcephalothin 
• 75-44-5 phosgene 

Downstream Products

• 135508-73-5 (6R,7R)-3-{[Bis-(2-chloro-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-77-9 (6R,7R)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxymethyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-76-8 (6R,7R)-3-{[Bis-(2-bromo-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-75-7 (6R,7R)-3-{[Bis-(2-chloro-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-74-6 (6R,7R)-3-{[Bis-(2-bromo-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-71-3 (6R,7R)-3-{[Bis-(2-hydroxy-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-70-2 (6R,7R)-3-{[Bis-(2-hydroxy-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-72-4 (6R,7R)-3-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenylcarbamoyloxymethyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Synthesis of beta-lactamase activated nitric oxide donors

In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.

Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'

A series of cephalosporin carbamates, functionalised with masked nitrogen mustards has been synthesised. There are potential prodrugs for interaction with a monoclonal antibody-β-lactamase tumor targeting system. The β-lactamase catalysed hydrolysis to ge