135586-33-3

Usage

Class

Thiadiazole derivatives

Biological Activities

Diverse

Potential Applications

Pharmaceutical

Studied for

Anti-cancer, anti-inflammatory, and anti-bacterial properties

Structural Feature

Presence of a pyridinyl group

Targeting

Specific biological pathways

Research and Development

Ongoing to discover new drugs with therapeutic potential

Upstream product

• 36209-51-5 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol 
• 75-36-5 acetyl chloride 
• 64-19-7 acetic acid 
• 54-85-3 isoniazid 
• 108-24-7 acetic anhydride 
• 61019-32-7 potassium 4-pyridinyldithiocarbazate 
• 15264-63-8 5-(4-pyridinyl)-1,3,4-oxadiazole-2-thiol 

Relevant academic research and scientific papers

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Synthesis of novel 1,2,4-triazoles, triazolothiadiazines and triazolothiadiazoles as potential anticancer agents

A series of new N-substituted-3-mercapto-1,2,4-triazoles (3a,b and 7a-d), triazolo[1,3,4]thiadiazines (5a,b) and triazolo[1,3,4]thiadiazoles (4a-d, 6 and 8a-d) have been synthesized starting from isonicotinic acid hydrazide. The structure of the newly synthesized compounds was confirmed on the basis of their spectral data and elemental analyses. All the compounds were screened for their in vitro anticancer activity against 6 human cancer cell lines and normal fibroblasts. Seven of the tested compounds (3a,b, 4c, 5a and 8b-d) exhibited significant cytotoxicity against most cell lines. Among these derivatives compound 4c exhibited equivalent cytotoxic effect to the standard CHS 828 against gastric cancer cell line (IC50 = 25 nM). Normal fibroblast cells (WI38) were affected to a much lesser extent (IC50 > 10,000 nM).

Synthesis, anti-inflammatory, analgesic, and antibacterial activities of some triazole, triazolothiadiazole, and triazolothiadiazine derivatives

This study is concerned with the synthesis of new 1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4- thiadiazines derivatives. Derivatives 3a-i were obtained by condensation of 4-amino-3-(4-pyridine)- 5-mercapto-1,2,4-triazole 1 with the appropriate aldehyde

Synthesis and pharmacological properties of 6-substituted 3-(pyridine-4-yl)-1,2,4-triazole [3,4-b][1,3,4]thiadiazoles

A number of new 6-substituted 3-(pyridine-4-yl) 1,2,4-triazole[3,4-b][1,3,4]thiadiazoles were synthesized and evaluated for their pharmacological activity. Some of them exhibited moderate MAO, antimalarial and in vitro antitumor activity.