135626-41-4Relevant academic research and scientific papers
Efficient generation of ortho -quinone methide: Application to the biomimetic syntheses of (±)-schefflone and tocopherol trimers
Liao, Daohong,Li, Houhua,Lei, Xiaoguang
, p. 18 - 21 (2012/02/04)
An efficient method using silver oxide-mediated oxidation for the synthesis of ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported.
Easy access to (±)-schefflone and espintanol
Osipov, Dmitry V.,Osyanin, Vitaly A.,Klimochkin, Yuri N.
, p. 917 - 919 (2012/06/04)
Oxidation of espintanol by silver oxide gives trimeric monoterpenoid (±)-schefflone via ortho-quinone methide intermediate. The heating of 6-[(dibenzylamino)methyl]-3-isopropyl-2,4-dimethoxyphenol also results in ortho-quinone methide intermediate which i
A total synthesis of the aromatic monoterpene espintanol
Zuniga, Adrian Covarrubias,Romero-Ortega, Moises,Avila Zarraga, Jose G.
, p. 527 - 529 (2007/10/03)
A synthesis of the leishmanicidal and trypanocidal monoterpene espintanol from dimethyl 2-isopropyl-3-oxoglutarate and 2-butynal using a Michael addition-Dieckmann cyclization as the key step is described.
A Short Synthesis of the Aromatic Monoterpene Espintanol
Wadsworth, David J.,Losch, Sabine
, p. 8673 - 8676 (2007/10/02)
A flexible and expedient synthesis of the leishmanicidal and trypanocidal monoterpene espintanol 1, first isolated in 1991 from the spruce Oxandra espintana, was achieved in seven steps and with an overal yield of 11percent.Key steps were the direct conve
