135673-72-2Relevant academic research and scientific papers
Preparation and diuretic properties of novel amiloride analogues
Russ,Ried,Ullrich,Mutschler
, p. 761 - 767 (1992)
Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6-substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physicochemical properties.
Homolytic acylation of methyl 3-amino-2-pyrazinecarboxylates
Ried,Russ Th.
, p. 581 - 582 (2007/10/02)
Homolytic acylation of methyl 3-amino-2-pyrazinecarboxylates 1 a-c under standard Minisci conditions afford the corresponding 5- or 6-monoacylated pyrazines 3 a-d or 4a,b in reasonable yields. With 1 a, complete selectivity in favor of the 5-acyl products is observed.
