Archiv der Pharmazie p. 761 - 767 (1992)
Update date:2022-07-29
Topics:
Russ
Ried
Ullrich
Mutschler
Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6-substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physicochemical properties.
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Doi:10.1016/S0040-4039(00)79723-1
(1991)Doi:10.1016/j.cclet.2011.11.001
(2012)Doi:10.1021/ja2112965
(2012)Doi:10.1002/ejoc.201101035
(2011)Doi:10.1016/j.carres.2011.12.007
(2012)Doi:10.1016/S0040-4039(00)79771-1
(1991)
