135697-21-1

Basic information

• Product Name: (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate
• Synonyms: (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate
• CAS NO: 135697-21-1
• Molecular Weight: 369.439
• Mol File: 135697-21-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate(135697-21-1)
• EPA Substance Registry System: (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate(135697-21-1)

Safety Data

• Hazardous Substances Data: 135697-21-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 17342-08-4 (S)-Pyroglutaminol 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 56-86-0 L-glutamic acid 

Downstream Products

• 188015-47-6 (S)-2-Hydroxy-5-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1038924-76-3 (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 135697-46-0 4-tert-Butyl-benzoic acid 2-({(S)-4-{(S)-4-tert-butoxycarbonylamino-5-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-pentanoylamino}-5-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-pentanoyl}-methyl-amino)-ethyl ester 
• 135697-42-6 {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-3-[(S)-1-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-3-(piperidin-1-ylcarbamoyl)-propylcarbamoyl]-propyl}-carbamic acid tert-butyl ester 
• 135697-40-4 (S)-2-<<4-<<(1,1-dimethylethoxy)carbonyl>amino>-5-<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>-1-oxopentyl>methylamino>ethyl 4-(1,2-dimethylethyl)benzoate 
• 135697-33-5 (S)-4-tert-Butoxycarbonylamino-5-[4-(4-tert-butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-pentanoic acid 4-nitro-phenyl ester 
• 135697-36-8 (S)-1,1-dimethylethyl <1-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-4-oxo-4-(1-piperidinylamino)butyl>carbamate 
• 135697-39-1 {(S)-1-[4-(4-tert-Butyl-benzoylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-3-[(2-hydroxy-ethyl)-methyl-carbamoyl]-propyl}-carbamic acid tert-butyl ester 
• 135697-26-6 (S)-γ-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<<4-(1,1-dimethylethyl)benzoyl>amino>-2-oxo-1(2H)-pyrimidinepentanoic acid 
• 135697-24-4 (S)-1,1-dimethylethyl 2-<<4-<<4-(1,1-dimethylethyl)benzoyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate 
• 135697-20-0 (S)-γ-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinepentanoic acid 
• 135697-18-6 (S)-1,1-dimethylethyl 2-<<4-(benzoylamino)-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-5-oxo-1-pyrrolidinecarboxylate 
• 188015-49-8 (S)-2-Methoxy-5-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 214334-42-6 (2S,5S)-2-Allyl-5-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

A class of histone acetylase p300 inhibitors, and application thereof

The invention discloses a class of histone acetylase p300 inhibitors, and application thereof, and belongs to the technical field of medicinal chemistry. The invention discloses a compound representedby a formula (I), or a stereochemical isomer, a solvate or a pharmaceutically acceptable salt thereof. According to the invention, the compound can effectively inhibit the activity of histone acetylase p300 and can effectively inhibit the proliferation activity of various tumor cells; the compound is combined with a CDK4/6 inhibitor to play a synergistic role in inhibiting proliferation of tumorcells; and the compound has good application prospects in preparation of histone acetylase inhibitors, preparation of drugs for preventing and/or treating cancers, metabolic diseases, neurological diseases or inflammations, and combination of drugs.

Straightforward synthesis of non-natural l-chalcogen and l-diselenide N-Boc-protected-γ-amino acid derivatives

The synthesis of new chiral seleno-, telluro-, and thio-N-Boc-γ-amino acids is described herein. These new compounds were prepared through a simple and short synthetic route, from the inexpensive and commercially-available amino acid l-glutamic acid. The products, with a highly modular character, were obtained in good to excellent yields, via hydrolysis of chalcogen pyroglutamic derivatives with overall retention of the l-glutamic acid stereochemistry. Also, an l-diselenide-N-Boc-γ-amino acid was prepared in good yield. This new synthetic route represents an efficient method for preparing new l-chalcogen- and l-diselenide-γ-amino acids with biological potential.

Acyclic Nucleic Acid Analogues: Synthesis and Oligomerization of γ,4-Diamino-2-oxo-1(2H)-pyrimidinepentanoic Acid and δ,4-Diamino-2-oxo-1(2H)-pyrimidinehexanoic Acid

Alkylation of the tosylates of N-t-Boc-5-(hydroxymethyl)-2-pyrrolidinone and N-t-Boc-6-(hydroxymethyl)-2-piperidinone with the sodium salt of cytosine in dimethyl sulfoxide, followed by acylation of the base exocyclic amine and selective opening of the lactam ring by alkaline hydrolysis, gave the title compounds, respectively, in protected form.Oligomerization was achieved by activation of the carboxylic group as the p-nitrophenyl ester and coupling with the free amine of another subunit in dimethlformamide or dimethyl sulfoxide.A hexamer of the pentanoic acid system could be easily prepared by stepwise coupling of the monomeric units or by block synthesis via trimers.The hexanoic acid derived hexamer could only be prepared by stepwise elongation, mostly due to problems of solubility for this backbone.