188015-49-8

Upstream product

• 135697-21-1 (S)-(1-tert-butoxycarbonyl-5-oxopyrrolidin-2-yl)-methyl-4-methylbenzenesulfonate 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 188015-47-6 (S)-2-Hydroxy-5-(toluene-4-sulfonyloxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 149-73-5 trimethyl orthoformate 

Relevant academic research and scientific papers

Stereoselective access to trans-2,5-disubstituted pyrrolidine derivatives by nucleophilic addition to bicyclic N-acyliminium ion

5-Alkoxy-pyrroloxazolidin-3-ones 1 were stereoselectively prepared from (S)-pyroglutamic acid. Treatment of 1 with a Lewis acid generated in situ the N-acyliminium 2, which was trapped by various π-nuclcophiles leading selectively to trans pyrrolidine derivatives 3.