13570-00-8

Usage

Uses

Used in Organic Synthesis:
3-(1H-Imidazol-2-yl)-pyridine is used as a building block in organic synthesis for the preparation of various biologically active molecules, due to its unique structure and reactivity.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-(1H-Imidazol-2-yl)-pyridine is used as a precursor for the development of new drugs, given its potential to form biologically active compounds.
Used in Anti-Inflammatory Applications:
3-(1H-Imidazol-2-yl)-pyridine is studied for its potential as an anti-inflammatory agent, which could be beneficial in the treatment of various inflammatory conditions.
Used in Antiviral Applications:
3-(1H-IMIDAZOL-2-YL)-PYRIDINE is also being investigated for its potential as an antiviral agent, which could be instrumental in developing treatments for viral infections.
Used in Coordination Chemistry:
3-(1H-Imidazol-2-yl)-pyridine is used as a ligand in coordination chemistry, where it forms complexes with various metal ions, which can have applications in areas such as catalysis and materials science.

InChI:InChI=1/C8H7N3/c1-2-7(6-9-3-1)8-10-4-5-11-8/h1-6H,(H,10,11)

Upstream product

• 110-86-1 pyridine 
• 50846-98-5 2-Diazo-2H-imidazole 
• 148747-91-5 N-(2,2-dimethoxyethyl)-3-pyridinecarboxamidine 
• 100-54-9 pyridine-3-carbonitrile 
• 22483-09-6 2,2-dimethoxyethylamine 
• 6302-53-0 2-(pyridin-3-yl)imidazoline 
• 59-67-6 nicotinic acid 
• 107-15-3 ethylenediamine 

Relevant academic research and scientific papers

Novel and chemoselective dehydrogenation of 2-substituted imidazolines with potassium permanganate supported on silica gel

Various types of 2-imidazolines are efficiently oxidized to the corresponding imidazoles using potassium permanganate supported on silica gel under mild conditions at room temperature. 2-Alkylimidazolines are selectively converted to their corresponding imidazoles in the presence of 2-arylimidazolines. Chemoselective oxidation of 2-imidazolines in the presence of other oxidizable functional groups such as sulfide, ether, aldehyde, acetal, and THP ether was also achieved by this reagent system.

Oxidation of 2-imidazolines to 2-imidazoles with sodium periodate catalyzed by polystyrene-bound manganese(III) porphyrin

In the present work, the dehydrogenation of 2-substituted imidazolines with sodium periodate in the presence of tetraphenylporphyrinatomanganese(III) chloride supported on polystyrene-bound imidazole, [Mn(TPP)Cl@PSI] is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by the [Mn(TPP)Cl@PSI]/NaIO4 catalytic system in a 1:2 CH3CN/H2O mixture under agitation with magnetic stirring. Ultrasonic irradiation enhanced the catalytic activity of this catalyst in the oxidation of 2-imidazolines and this led to shorter reaction times and higher product yields. This catalyst could be reused several times without significant loss of its catalytic activity.

Dehydrogenation of 2-imidazolines with sodium periodate catalyzed by manganese(III) tetraphenylporphyrin

In the present work, dehydrogenation of 2-substituted imidazolines with sodium periodate in the presence of tetraphenylporphyrinatomanganese(III) chloride, [Mn(TPP)Cl], is reported. A wide variety of 2-imidazolines efficiently converted to their corresponding imidazoles by [Mn(TPP)Cl]/NaIO4 catalytic system at room temperature in 1:2, CH3CN/H2O mixture. The effect of reaction parameters such as kind of solvent and catalyst amount was also investigated.

Mild, efficient, and chemoselective dehydrogenation of 2-imidazolines, bis-imidazolines, and N-substituted-2-imidazolines with potassium permanganate supported on montmorillonite K-10

Different types of 2-imidazolines, bis-imidazolines, and N-substituted-2-imidazolines are efficiently oxidized to their corresponding imidazoles with potassium permanganate (KMnO4) supported on montmorillonite K-10 under very mild conditions. The procedure is very simple and no strict conditions were required. Selective dehydrogenation of 2-alkyl-2-imidazolines in the presence of 2-aryl-2-imidazolines is a noteworthy advantage of this method and can be considered as a useful practical achievement in these reactions.

Alumina supported potassium permanganate: An efficient reagent for chemoselective dehydrogenation of 2-imidazolines under mild conditions

An efficient method for the oxidation of 2-imidazolines to their corresponding imidazoles using KMnO4/Al2O3 under very mild reaction conditions is reported. Selective oxidation of 2-alkylimidazolines was also performed in the presence of 2-arylimidazolines and other functional groups such as sulfide, ether, aldehyde, acetal and THP ether. Potassium permanganate supported on alumina was found to be an efficient reagent system for dehydrogenation of 2-imidazolines to imidazoles under mild conditions at room temperature. Selective oxidation of 2-alkylimidazolines in the presence of 2-arylimidazolines was achieved using this reagent system. 2-Imidazolines were also selectively converted to their corresponding imidazoles in the presence of other oxidizable functional groups such as sulfide, ether, aldehyde, acetal and THP ether. The oxidation procedure described here is easy to carry out and does not require strict reaction conditions.

Multi-wall carbon nanotube supported manganese(III) porphyrin: An efficient and reusable catalyst for oxidation of 2-imidazolines with sodium periodate

The oxidation of 2-substituted imidazolines with sodium periodate catalyzed by tetrakis(p-aminophenyl)-porphyrinatomanganese(III) chloride, [Mn(TNH 2PP)Cl], supported on functionalized multi-wall carbon nanotubes is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by this catalytic system. When the same reaction was subjected to ultrasonic irradiation, the reaction times were reduced significantly and the product yields were increased. This catalyst could be reused several times without significant loss of activity. The effects of reaction parameters such catalyst amount, choice of solvent, and the effects of ultrasonic irradiation on the catalytic activity have been investigated.

Rapid and efficient biomimetic oxidation of 2-imidazolines to their corresponding imidazoles with NaIO4 catalyzed by Mn(salophen)Cl

Rapid and efficient oxidation of 2-substituted imidazolines with sodium periodate is reported. The Mn(III)-salophen/NaIO4 catalytic system efficiently converted 2-imidazolines to their corresponding imidazoles at room temperature in 2: 1, CH3CN/H2O mixture.

Stabilizing volatile liquid chemicals using co-crystallization

A convenient, effective, and scalable protocol for stabilizing volatile liquid chemicals is reported. Through the use of halogen-bond driven co-crystal synthesis, several examples of liquid iodoperfluoroalkanes are transformed into crystalline materials with low-vapor pressure, considerable thermal stability, and moisture resistance. The target compounds can subsequently be re-generated through simple solvent-extractions.

A convenient procedure for preparing hetarylamides and their analogs by dehydrogenation of the corresponding imidazoles

Conditions of aromatization of 2-(2-hetaryl)imidazolines and their analogs with various dehydrogenating agents were examined. A new catalytic system, Pd/C-diphenyl oxide, was studied, and the optimal catalyst:imidazoline ratio ensuring formation of 2-substituted imidazoles in high yield was found.

A simple and convenient one-pot method for the preparation of heteroaryl-2-imidazoles from nitriles

A simple, convenient and high-yielding one-pot method for the synthesis of 2-heterocycle-substituted imidazoles from the corresponding nitriles has been developed. The procedure is easily scaleable and the workup does not involve chromatography. This synthesis is also applicable to the preparation of imidazoles with electron-poor aryl substituents.