1357098-87-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of chalcone- containing shikonin derivatives as inhibitors of tubulin polymerization
Qiu, Han-Yue,Wang, Fang,Wang, Xue,Sun, Wen-Xue,Qi, Jin-Liang,Pang, Yan-Jun,Yang, Rong-Wu,Lu, Gui-Hua,Wang, Xiao-Ming,Yang, Yong-Hua
, p. 399 - 406 (2017)
The biological importance of microtubules in mitosis makes them an interesting target for the development of anticancer agents. In this study, a series of novel chalcone-containing shikonin derivatives was designed, synthesized, and evaluated for biologic
Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents
Kamal, Ahmed,Mallareddy, Adla,Suresh, Paidakula,Lakshma Nayak,Shetti, Rajesh V.C.R.N.C.,Sankara Rao,Tamboli, Jaki R.,Shaik, Thokhir B.,Vishnuvardhan,Ramakrishna
, p. 530 - 545 (2012/02/14)
A series of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxin congeners have been synthesized. All the twenty nine compounds were evaluated for anticancer activity against five human cancer cell lines (A-549, A375, MCF-7, HT-29 and ACHN). Some of the synthesized compounds showed good anticancer activity that is comparable to etoposide. The IC50 of compounds 17a and 17f is 2.7 and 2.1 μM respectively against A-549 cancer cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis.
