1357165-74-2

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 4363-35-3 Dihydroxy-styryl-boran 
• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 100-42-5 styrene 

Relevant academic research and scientific papers

N2Phos - an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water

A new biaryl phosphine-containing ligand from an active palladium catalyst for ppm level Suzuki-Miyaura couplings, enabled by an aqueous micellar reaction medium. A wide array of functionalized substrates including aryl/heteroaryl bromides are amenable, as are, notably, chlorides. The catalytic system is both general and highly effective at low palladium loadings (1000-2500 ppm or 0.10-0.25 mol%). Density functional theory calculations suggest that greater steric congestion in N2Phos induces increased steric crowding around the Pd center, helping to destabilize the 2?:?1 ligand-Pd(0) complex more for N2Phos than for EvanPhos (and less bulky ligands), and thereby favoring formation of the 1?:?1 ligand-Pdocomplex that is more reactive in oxidative addition to aryl chlorides.

Metal-free synthesis of 2-alkenyl/alkynyl-5-nitropyridines using a three-component ring transformation

A metal-free, facile, and efficient protocol for synthesizing a series of 2-alkenyl/alkynyl-5-nitropyridines was developed by using a three-component ring transformation of 1-methyl-3,5- dinitro-2-pyridone with α,β-unsaturated ketones and ammonium acetate

Combination of palladium and oleic acid coated-magnetite particles: Characterization and using in Heck coupling reaction with magnetic recyclability

The magnetic Fe3O4 nanoparticles were prepared by co-precipitation method and coated with oleic acid. The oleic acid coated Fe3O4 (Fe@OA) particles were used for the immobilization of palladium particles to prod

Palladium supported on oleic acid-coated magnetic nanoparticle as an efficient catalyst for Heck coupling reaction in aqueous media

A magnetically recoverable heterogeneous catalyst was synthesized by immobilization of Pd on the surface of oleic acid coated Fe3O4 nanoparticle. This catalyst was used for Heck coupling reaction of styrene with various aryl halides in aqueous media. The catalyst/product separation could be easily achieved with external magnetic field.

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.