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Chemical Science
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complex and making formation of the more reactive 1 : 1 LPdo
complex more accessible when compared to EvanPhos. The
monoligated 12-electron (N2Phos)Pd catalyst is then especially
prone towards oxidative addition to aryl chlorides.45
B. H. Lipshutz, Angew. Chem., Int. Ed., 2016, 55, 4914–4918;
(b) B. S. Takale, R. R. Thakore, S. Handa, F. Gallou,
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B. H. Lipshutz, Green Chem., 2018, 20, 3436–3443; (b)
R. R. Thakore, B. S. Takale, F. Gallou, J. Reilly and
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16 (a) B. H. Lipshutz, S. Ghorai and M. Cortes-Clerget, Chem.–
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Conflicts of interest
The authors have no conicts of interest to declare.
Acknowledgements
Financial support provided by the NSF (18-56406) and Novartis
is warmly acknowledged. Use was made of computational
facilities purchased with funds from the National Science
Foundation (CNS-1725797) and administered by the Center for
Scientic Computing (CSC). The CSC is supported by the Cal-
ifornia NanoSystems Institute and the Materials Research
Science and Engineering Center (MRSEC; NSF DMR 1720256) at
UC Santa Barbara. The soware used for 3-D drawings was from
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