1357289-08-7

Basic information

• Product Name: DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
• Synonyms: DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate;Dolutegravir DL5A;Dimethyl 3-(benzyloxy)-1-(2,2-;Dimethyl 1-(2,2-dimethoxyethyl)-4-oxo-3-phenylmethoxypyridine-2,5-dicarboxylate;2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-, 2,5-dimethyl ester
• CAS NO: 1357289-08-7
• Molecular Formula: C₂₀H₂₃NO₈
• Molecular Weight: 405.39852
• EINECS: -0
• Mol File: 1357289-08-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 557.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: -1.29±0.10(Predicted)
• CAS DataBase Reference: DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate(1357289-08-7)
• EPA Substance Registry System: DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate(1357289-08-7)

Safety Data

• Hazardous Substances Data: 1357289-08-7(Hazardous Substances Data)

Usage

General Description

DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate is a chemical compound composed of dimethyl, benzyloxy, diMethoxyethyl and dihydropyridine-2,5-dicarboxylate groups. It is used in pharmaceutical research and drug development due to its potential as a calcium channel blocker. DiMethyl 3-(benzyloxy)-1-(2,2-diMethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate has been studied for its potential therapeutic effects in treating cardiovascular diseases, hypertension, and other related conditions. Its chemical structure also makes it a target for further medicinal chemistry research to optimize its pharmacological properties for potential drug development.

Upstream product

• 67354-34-1 ethyl 4-benzyloxyacetoacetate 
• 124-41-4 sodium methylate 
• 22483-09-6 2,2-dimethoxyethylamine 
• 1246616-66-9 dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate 
• 1246616-65-8 methyl 4-benzyloxy-2-((dimethylamino)methylene)acetoacetate 
• 32807-28-6 Methyl 4-chloroacetoacetate 
• 100-51-6 benzyl alcohol 
• 82961-76-0 4-benzyloxy-3-oxobutyric acid methyl ester 

Downstream Products

• 1206102-11-5 (4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide 
• 1357289-10-1 C₂₁H₂₂N₂O₆ 
• 1246617-67-3 C₁₈H₁₇NO₇ 
• 1229006-25-0 methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate 
• 1357289-24-7 C₂₈H₂₉F₂N₃O₆ 
• 1357289-26-9 C₂₇H₂₇F₂N₃O₆ 
• 1357289-27-0 C₂₇H₂₅F₂N₃O₅ 
• 1229006-21-6 1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester 
• 1973401-99-8 1-(2,2-dimethoxyethyl)-5-(benzyloxy)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 1051375-19-9 (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino-[2,1-b][1,3]oxazine-9-carboxamide sodium salt 
• 1051375-16-6 dolutegravir 

Relevant articles and documents

Practical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium

A highly efficient and practical synthetic method for the preparation of pyrone diesters was established. The pyrone diester 3c can be prepared from readily available starting materials on a multihundred gram scale. The pyrone diester 3c can easily be converted to dolutegravir sodium (1). The synthetic route demonstrated herein provides an efficient and atom-economical synthetic method for preparing this potent anti-HIV agent.

PROCESS FOR THE PREPARATION OF HIV INTEGRASE INHIBITORS

The present invention provides compound of formula (XVII), wherein P is hydroxyl protecting group; R2 and R3 are independently lower alkyl or R2 and R3 can be alkyl and joined to form a 5-, 6- or 7-membered ring; R4 is lower alkyl, and process for its preparation.

PROCESS FOR PREPARING COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].