135782-11-5

Basic information

• Product Name: 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE
• Synonyms: 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE;2-Benzylhexahydropyrano[3,4-c]pyrrol-4(2H)-one;Hexahydro-2-(phenylmethyl)pyrano[3,4-c]pyrrol-4(1H)-one;2-benzyl-1,3,3a,6,7,7a-hexahydropyrano[3,4-c]pyrrol-4-one
• CAS NO: 135782-11-5
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.29
• Product Categories: pharmacetical
• Mol File: 135782-11-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 384.8°Cat760mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 3.99E-06mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE(135782-11-5)
• EPA Substance Registry System: 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE(135782-11-5)

Safety Data

• Hazardous Substances Data: 135782-11-5(Hazardous Substances Data)

Usage

General Description

2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE, also known as THP-1, is a chemical compound with a unique structure containing a hexahydro-pyrano-pyrrolone ring system. It is commonly used as a building block in the synthesis of various biologically active molecules and pharmaceutical drugs. THP-1 has been studied for its potential as an anti-inflammatory and analgesic agent, as well as its activity against various types of cancer cells. Additionally, this compound has been found to exhibit antimicrobial and antiviral properties, making it a valuable tool for medicinal chemistry research and drug development. Overall, 2-BENZYL-HEXAHYDRO-PYRANO[3,4-C]PYRROL-4-ONE is a versatile and important chemical that has the potential for diverse biological and pharmaceutical applications.

InChI:InChI=1/C14H17NO2/c16-14-13-10-15(9-12(13)6-7-17-14)8-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2

Upstream product

• 2081-44-9 Tetrahydro-pyran-4-ol 
• 3174-74-1 dihydropyran 
• 3393-45-1 5,6-dihydro-pyran-2-one 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 93102-06-8 N-benzyl-N-(butyloxymethyl)trimethylsilylmethylamine 

Downstream Products

• 1438072-95-7 2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one 
• 1438081-82-3 2-(1-benzyl-4-(hydroxymethyl)pyrrolidin-3-yl)ethanol 
• 1438081-87-8 2-benzyloctahydropyrano[3,4-c]pyrrole 
• 1438073-13-2 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydropyrano[3,4-c]pyrrol-2(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-93-1 2-(3-((4-((4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydropyrano[3,4-c]pyrrol-4(2H)-one 
• 171906-65-3 tert-butyl 3-azabicyclo[3.2.0]heptan-1-ylcarbamate 
• 115594-43-9 (1R,3R,4S)-1-Benzyl-3-ethoxycarbonyl-1-azonia-bicyclo[2.2.1]heptane; bromide 
• 129656-37-7 1-benzyl-3-ethoxycarbonyl-1-azoniabicyclo<2.2.1>heptane bromide 
• 123916-90-5 endo-3-acetyl-1-azabicyclo<2.2.1>heptane 
• 130513-77-8 (1R,3S,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carbonyl chloride 
• 115595-00-1 (1R,3S,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid 
• 135782-12-6 2-benzyl-4-oxoperhydropyrano<3,4-c>pyrrolium hydrogen maleate 
• 114704-10-8 endo-ethyl 1-azabicyclo[2.2.1]heptane-3-carboxylate 
• 135782-13-7 1-benzyl-3-(2-bromoethyl)-4-ethoxycarbonylpyrrolidinium bromide 

Relevant articles and documents

ISOQUINOLINESULFONYL DERIVATIVE AS RHO KINASE INHIBITOR

The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

A Synthesis of 1-Azabicycloheptane-3-carboxylic Acid Esters in Enantiomerically Pure Form

A novel synthesis of ethyl 1-azabicycloheptane-3-carboxylate via 1-benzylperhydropyranopyrrol-4-one and 1-benzyl-3-(2-bromoethyl)-4-ethoxycarbonylpyrrolidinium bromide is described.Modification of the method, by incorporation of a chiral substituted benzyl group on the nitrogen atom, has led to the first reported process for the preparation of these esters in enantiomerically pure form.The absolute configuration of the bicyclic esters was deduced by X-ray crystallography of an intermediate, 2-perhydropyranopyrrole-4-one.