1358778-36-5

Basic information

• Product Name: (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
• Synonyms: (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
• CAS NO: 1358778-36-5
• Molecular Weight: 462.567
• Mol File: 1358778-36-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide(1358778-36-5)
• EPA Substance Registry System: (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide(1358778-36-5)

Safety Data

• Hazardous Substances Data: 1358778-36-5(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 153034-80-1 2-Fluoro-4-iodo-3-methylpyridine 
• 1358778-34-3 ethyl (2R)-4-(4-iodo-3-methyl-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)butanoate 
• 1227571-05-2 4-iodo-3-methylpyridin-2(1H)-one 
• 1312478-48-0 (2R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate 
• 1312478-47-9 ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate 
• 6723-30-4 O-2-tetrahydro-2H-pyranhydroxylamine 
• 1358778-35-4 (2R)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanoic acid 

Downstream Products

• 1358778-33-2 (2R)-N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide 

Relevant articles and documents

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious Gram-negative infections

The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.