1360171-47-6Relevant academic research and scientific papers
Synthesis of novel pyranoquinones using an acyl radical cyclization strategy
Donner, Christopher D.,Casana, Myriam I.
, p. 1105 - 1107 (2012)
The thiol-catalysed cyclization of acyl radicals generated directly from benzaldehyde precursors has been investigated. Hindered β- benzyloxyacrylates cyclize efficiently providing a tin-free radical cyclization approach to the serine/threonine kinase AKT inhibitor frenolicin B, whilst γ-aryloxy crotonates give good yields of benzopyran-4-ones. This method is applied to the synthesis of a novel tetracyclic analogue of the pyranonaphthoquinone antibiotics.
