13605-65-7

Upstream product

• 534-07-6 1,3-Dichloroacetone 
• 603-35-0 triphenylphosphine 

Downstream Products

• 13605-66-8 1-chloro-3-(triphenylphosphoranylidene)acetone 
• 108175-89-9 3-<3-(2-Oxopropyl)thio><1,2,4>triazolyltriphenylphosphonium chloride hydrochloride 
• 63198-83-4 1-imidazol-1-yl-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one 
• 33502-03-3 1-phenoxy-3-(triphenylphosphoranylidene)-2-propanone 
• 96056-26-7 2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)propyl]-1H-isoindole-1,3(2H)-dione 
• 497063-21-5 1-(1-phenylbut-3-en-1-yloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 497063-23-7 1-(1-isopropylpent-4-en-1-yloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 497063-20-4 1-(1-isopropylbut-3-en-1-yloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 497063-22-6 1-(1,1-dimethylbut-3-en-1-yloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 497063-19-1 1-(1-isopropylprop-2-en-1-yloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 942056-52-2 1-(hex-5-enyloxy)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 
• 942056-43-1 1-(benzyl but-3-en-1-ylamino)-3-(triphenyl-λ⁵-phosphoranylidene)propan-2-one 

Relevant academic research and scientific papers

Synthesis, spectral characterization, and X-ray crystal structure of Pd(II) complexes containing the orthometallated C,C-chelating ligand C 6H 4-PPh 2C(H)C(O)CH 2Cl

The ylide-phosphonium salt [PPh3CH2C(O)CH 2Cl]+Cl- (1) reacted with Pd(OAc)2 to give the chloro-bridged dinuclear complex [Pd{C(H)PPh3C(O)CH 2Cl}(μ-Cl)(OAc)]2/su

CHLOROACETONYLTRIPHENYLPHOSPHONIUM ET PHOSPHORANNE CORRESPONDANT, ETUDE PHYSICOCHIMIQUE ET CONFORMATION

The structures of chloroacetonyltriphenylphosphonium and the corresponding phosphorane have been studied by IR, NMR (1H, 13C, 31P) and X-ray crystallography.The compounds have analogous conformations, especially when an enolic form of the phosphonium salt is considered.The molecules are nearly planar with phosphorus, oxygen and chlorine atoms being cis-cis with each other.This arrangement explains the ability of the phosphorane to undergo reactions in which these reactive centers are involved.

New phosphorus ylide palladacyclic: Synthesis, characterization, X-Ray crystal structure, biomolecular interaction studies, molecular docking and in vitro cytotoxicity evaluations

The ylide-phosphonium salt [PPh3CH2C(O)CH2Cl]+Cl? was reacted with Pd(OAc)2 to give the chloro-bridged dinuclear complex [Pd{C(H)PPh3C(O)CH2Cl}(μ-Cl)(OAc)]2, which experienced bridge cleavage reactions with triphenylphosphine (PPh3) and pyridine (Py), and to prepare the new orthometallated complexes [Pd{(C,C)–C6H4PPh2C(H)C(O)CH2Cl}L]Cl, [L = PPh3 (1) and Py (2)]. The complexes were identified and characterized using various techniques. X-ray crystallography was used to determine the crystal structure of 1, which revealed the presence of an orthometallated C6H4-PPh2 unit. CT-DNA binding interaction of the synthesis compounds was tested by fluorescence spectroscopy, UV–Vis absorption spectroscopy, and the viscometric titration method. The analysis of the obtained data indicated that the Pd complexes could bind to DNA via groove binding by the partial intercalation mode. The emission titration of bovine serum albumin (BSA) with two Pd complexes showed a static process for the fluorescence quenching mechanism of BSA. In addition, the results of competitive binding by Eosin-Y, Ibuprofen and Digoxin site markers revealed that the complexes were bound to the site I of BSA. The donor (BSA) - acceptor (Pd complexes) distance was calculated using fluorescence resonance energy transfer (FRET). Notably, molecular docking studies were used for the determination of DNA and BSA-Pd (II) complexes binding. Finally, the two complexes exhibited significant in vitro cytotoxicity against human leukemic T cell (Jurkat) and chronic myelogenous leukemia (K562) cancer cell lines using MTT([3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide] colorimetric. In cell cycle analysis conducted on Jurkat and K562 cells treated with ligand and Pd complexes, a decrease in DNA cell content and shift in the main population of cells toward the subG1 phase were observed.

FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF

The invention relates to compounds of formula I, in which Y, Ar1, Ar2, X, R1 and R2 are defined herein, and to their use in a variety of biological imaging techniques and therapeutic methods. In aspects, the invention relates to conjugates comprising the compounds of formula I and their associated uses and therapeutic uses.

From phosphonium salts to binuclear ortho-palladated phosphorus ylides

This current piece of research presents an easy and direct way for the synthesis of binuclear ortho-palladated phosphorus ylide derivatives of acetone and chloroacetone in high yield and high purity by the reaction of the phosphonium salts [CH3COCH2PPh3]Cl (1) and [ClCH2COCH2R]Cl (R = PPh3 (2), R = P(PhMe)3 (3)) with palladium(II) acetate in methanol under mild conditions to afford the dimeric orthopalladated complexes, [Pd(CH3COCHPPh3)(μ-Cl)]2 (4), [Pd(ClCH2COCHPPh3)(μ-Cl)]2 (5) and [Pd(ClCH2COCHP(PhMe)3)(μ-Cl)]2 (6).

AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

One-pot eschenmoser episulfide contractions in DMSO: Applications to the synthesis of fuligocandins A and B and a number of vinylogous amides

Practical total syntheses of the natural products fuligocandin A (2a) and fuligocandin B (3) have been achieved through a convergent strategy depending on the Eschenmoser episulfide contraction as a key step. Conducting the reaction in DMSO proved to be an efficient and general method for the synthesis of a variety of vinylogous amides, such as azepan-2- ylidenepropan-2-one. 2011 American Chemical Society.

Total synthesis of fuligocandines A and B

A practical synthesis of the biologically active cycloanthranilylproline derivatives fuligocandines A and B is described, starting from l-proline and isatoic anhydride, employing an Eschenmoser episulfide contraction as the key step.

A convergent total synthesis of (+)-febrifugine

Febrifugine was synthesized in ten steps from N-Boc 4-aminobutan-1-ol by a convergent approach. Georg Thieme Verlag Stuttgart.

Synthesis of 3-oxooxa- and 3-oxoazacycloalk-4-enes by ring-closing metathesis. Application to the synthesis of an inhibitor of cathepsin K

3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(ω-alkenyloxy)- and 1-(ω-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K.