136057-73-3

Basic information

• Product Name: -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone
• CAS NO: 136057-73-3
• Molecular Weight: 273.332
• Mol File: 136057-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone(136057-73-3)
• EPA Substance Registry System: -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone(136057-73-3)

Safety Data

• Hazardous Substances Data: 136057-73-3(Hazardous Substances Data)

Upstream product

• 35086-87-4 (E)-2-methyl-3-phenylacryloyl chloride 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 

Downstream Products

• 79563-27-2 4(S)-(1-methylethyl)-3-(2(R)-methyl-1-oxo-3-phenylpropyl)-2-oxazolidinone 
• 136088-23-8 (S)-4-Isopropyl-3-((2S,3S)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 
• 136088-24-9 (S)-4-Isopropyl-3-((2S,3R)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 
• 136057-79-9 (S)-4-Isopropyl-3-((2R,3S)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 
• 136088-22-7 (S)-4-Isopropyl-3-((2R,3R)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 

Relevant articles and documents

Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem

A high degree of diastereoselectivity has been achieved on the asymmetric construction of two contiguous stereocenters by the conjugate addition of thiols to α,β-unsaturated imides possessing Evans's chiral auxiliary. Addition reactions of thiophenol to chiral E- and Z-2-methylcrotonyl imides 4 proceeded with high diastereoface selectivities. Diastereoselectivities were discussed when E- and Z-imides 4 and 5 were used as the substrates. A successful application was demonstrated by the formal synthesis of a clinically useful cardiac drug, (+)-diltiazem.