79563-27-2

Upstream product

• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 80698-13-1 C₁₃H₁₆O₄ 
• 77877-19-1 N-isopropyl oxazolidinone 
• 100-39-0 benzyl bromide 
• 136088-23-8 (S)-4-Isopropyl-3-((2S,3S)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 
• 136088-24-9 (S)-4-Isopropyl-3-((2S,3R)-2-methyl-3-phenyl-3-phenylsulfanyl-propionyl)-oxazolidin-2-one 
• 144154-40-5 (+/-)-3-(1-oxopropyl)-4-(1-methylethyl)-2-oxazolidinone 
• 77-92-9 citric acid 
• 136057-73-3 -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone 
• 136057-74-4 -4-(1-methylethyl)-3-(2-methyl-1-oxo-3-phenyl-2-propenyl)-2-oxazolidinone 
• 35086-87-4 (E)-2-methyl-3-phenylacryloyl chloride 

Downstream Products

• 77943-96-5 (2R)-2-methyl-3-phenyl-1-propanol 
• 14367-67-0 2-methyl-3-phenylpropionic acid 
• 80698-12-0 benzyl (R)-2-methyl-3-phenylpropanoate 
• 29393-16-6 methyl (2R)-2-methyl-3-phenylpropanoate 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 5445-77-2 (2R)-2-methyl-3-phenylpropanal 

Relevant academic research and scientific papers

Stereocontrolled Syntheses of Seven-Membered Carbocycles by Tandem Allene Aziridination/[4+3] Reaction

A tandem allene aziridination/[4+3]/reduction sequence converts simple homoallenic sulfamates into densely functionalized aminated cycloheptenes, where the relative stereochemistry at five contiguous asymmetric centers can be controlled through the choice

Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.

Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem

A high degree of diastereoselectivity has been achieved on the asymmetric construction of two contiguous stereocenters by the conjugate addition of thiols to α,β-unsaturated imides possessing Evans's chiral auxiliary. Addition reactions of thiophenol to chiral E- and Z-2-methylcrotonyl imides 4 proceeded with high diastereoface selectivities. Diastereoselectivities were discussed when E- and Z-imides 4 and 5 were used as the substrates. A successful application was demonstrated by the formal synthesis of a clinically useful cardiac drug, (+)-diltiazem.

Enantioselective synthesis of a putative hexaketide intermediate in the biosynthesis of the squalestatins

A convergent synthesis of (3R, 5Z, 8E, 10R)-3-hydroxy-8,10-dimethyl-11-phenylundec-5,8-dienoic acid 4, a putative hexaketide intermediate in the biosynthesis of the squalestatins, is described. A key step in the assembly of the carbon framework is the coupling of alkyne 19 with allylic bromide 13 giving, after further functional group manipulations, the target compound as a single diastereomer. The approach may be adapted for the preparation of the corresponding (3S, 5Z, 8E, 10R)-isomer as well as for the incorporation of carbon-13 labels required for biosynthetic studies.

Herpes ribonucleotide reductase inhibitors

Disclosed herein are compounds of the formula STR1 wherein R1 is hydrogen or (1-4C) alkyl, R2 is (1-4C) alkyl or a therapeutically acceptable salt thereof. The compounds are useful for treating herpes infections.