1360702-27-7

Upstream product

• 3282-30-2 pivaloyl chloride 
• 116599-39-4 (4-chloro-3-nitrophenyl)methanamine hydrochloride 
• 100398-63-8 4-chloro-3-nitro-benzylamine 

Downstream Products

• 1380920-99-9 N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide 
• 1380919-26-5 N-{4-chloro-3-[3-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1380921-23-2 N-(4-chloro-3-{3-[2-methylamino-5-(4-trifluoromethyl-piperidin-1-yl)-phenyl]-thioureido}-benzyl)-2,2-dimethyl-propionamide 
• 1380919-20-9 N-{4-chloro-3-[5-chloro-6-(2-dimethylcarbamoyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1380919-16-3 N-{4-chloro-3-[6-chloro-5-(3,3-difluoropyrrolidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]benzyl}-2,2-dimethyl-propionamide 
• 1360699-14-4 N-{4-chloro-3-[6-(4-bromo-phenylcarbamoyl)-5-(2,2-difluoro-ethoxy)-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1360702-29-9 N-(4-chloro-3-{N'-[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-5-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide 
• 1360702-28-8 N-(3-amino-4-chlorobenzyl)pivalamide 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.

2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION

This invention relates to compounds of formula (I), their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the 10 treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2,R7, R8, R9, Ra, Rb have meanings given in the description.

2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of

NEW COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of i