1362020-26-5

Basic information

• Product Name: (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenyl-1H-pyrazol-4-yl)methanone
• Synonyms: (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenyl-1H-pyrazol-4-yl)methanone
• CAS NO: 1362020-26-5
• Molecular Weight: 425.875
• Mol File: 1362020-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenyl-1H-pyrazol-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenyl-1H-pyrazol-4-yl)methanone(1362020-26-5)
• EPA Substance Registry System: (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenyl-1H-pyrazol-4-yl)methanone(1362020-26-5)

Safety Data

• Hazardous Substances Data: 1362020-26-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 569-37-9 ethyl 3-oxo-2-benzoylbutanoate 
• 54952-71-5 5-methyl-3-phenyl-1H-pyrazole-4-carboxylic acid 
• 114878-60-3 1-(2-chloro-4-nitro-phenyl)piperazine 

Relevant articles and documents

Design, synthesis, and in vitro biological evaluation of 1 H -1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

The influenza virus nucleoprotein (NP) is an emerging target for anti-influenza drug development. Nucleozin (1) and its closely related derivatives had been identified as NP inhibitors displaying anti-influenza activity. Utilizing 1 as a lead molecule, we successfully designed and synthesized a series of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents. One of the most potent compounds, 3b, inhibited the replication of various H3N2 and H1N1 influenza A virus strains with IC 50 values ranging from 0.5 to 4.6 μM. Compound 3b also strongly inhibited the replication of H5N1 (RG14), amantidine-resistant A/WSN/33 (H1N1), and oseltamivir-resistant A/WSN/1933 (H1N1, 274Y) virus strains with IC 50 values in sub-μM ranges. Further computational studies and mechanism investigation suggested that 3b might directly target influenza virus A nucleoprotein to inhibit its nuclear accumulation.