136465-78-6

Basic information

• Product Name: N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide
• Synonyms: N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide
• CAS NO: 136465-78-6
• Molecular Weight: 531.695
• Mol File: 136465-78-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide(136465-78-6)
• EPA Substance Registry System: N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide(136465-78-6)

Safety Data

• Hazardous Substances Data: 136465-78-6(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 1055033-80-1 Methanesulfonic acid (1R,2S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-1-(tetrahydro-pyran-2-yloxymethyl)-propyl ester 
• 1054798-68-3 2-[(1S,2R)-1-Benzyl-2-hydroxy-3-(tetrahydro-pyran-2-yloxy)-propyl]-isoindole-1,3-dione 
• 1026632-96-1 2-[(S)-1-Benzyl-2-oxo-3-(tetrahydro-pyran-2-yloxy)-propyl]-isoindole-1,3-dione 
• 136465-83-3 2(R)-(Methanesulfonyloxy)-4-phenyl-3(S)-phthalimido-1-butanol 
• 32150-91-7 phthaloyl-L-phenylalanyl chloride 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 149182-72-9 (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide 
• 1064005-84-0 (S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbonyl chloride 
• 79261-58-8 (S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester 
• 136465-82-2 1-Hydroxy-4-phenyl-3(S)-phthalimido-2-butanone 
• 74163-81-8 L-Tic-OH 
• 63-91-2 L-phenylalanine 
• 128019-40-9 (3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide 

Downstream Products

• 127779-20-8 Saquinavir 
• 137431-06-2 2-[3(S)-[(L-asparaginyl)-amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert-butyl-decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide 
• 136522-18-4 2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide 
• 136522-17-3 cis-N-butyldecahydro-2-<2(R)-hydroxy-4-phenyl-3(S)-aminobutyl>-(4aS,8aS)-isoquinoline-3(S)-carboxamide 

Relevant articles and documents

Synthesis of the HIV-proteinase inhibitor Saquinavir: A challenge for process research

The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir (1), a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.