13648-32-3Relevant academic research and scientific papers
Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement
Wu, Xiaoyu,Ding, Guangni,Yang, Liqun,Lu, Wenkui,Li, Wanfang,Zhang, Zhaoguo,Xie, Xiaomin
supporting information, p. 5610 - 5613 (2018/09/12)
An alkoxide-catalyzed hydrosilylation of cyclic imides to isoquinolines was realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence of a base catalyst, and then the carbonyl reduction, followed by siloxy elimination.
Metal-free C-N cross-coupling of electrophilic compounds and N-haloimides
Zhang, Luyan,Li, Yanru,Jin, Long-Yi,Liang, Fushun
, p. 65600 - 65603 (2015/08/18)
When DBU is added, the cross-coupling reaction between alkyl halides (halogen = Cl, Br and I) and N-haloimides (halogen = Cl, Br) occurs, resulting in the formation of aminated products. A halogen bond activated nucleophilic substitution mechanism was proposed. The methodology represents an elegant example of applying the halogen bond activation strategy in an organic transformation.
Photochemistry of ω-Phthalimidoalkanoic Acid Derivatives Syntheses of Multicyclic Fused Hydropyrazines and 1,4-Diazepines
Takechi, Haruko,Machida, Minoru,Kanaoka,Yuichi
, p. 859 - 868 (2007/10/02)
Photochemical reactions of phthalimides having various carbonyl functions (amides 3a-h, esters 11,14, and thioester 17) in their N-alkyl side chain are studied.By irradiation fused hydropyrazines (4a, e, g, h) and hydro-1,4-diazepines (4b, f) were formed from amide derivatives 3 through photocyclization, whereas the esters 11,14 showed addition and reduction reactions of the imide carbonyl group, and thioester 17 showed Norrish-type I reaction of the thioester moiety, in each case, however, without yielding cyclized products.
