136496-88-3

Upstream product

• 150250-34-3 tetraethyl 4-hydroxybutylene-1,1-bisphosphonate 
• 925684-59-9 tetraethyl 3-(t-butoxycarbonyl)propylene-1,1-bisphosphonate 
• 150250-33-2 tetraethyl 4-(tetrahydro-2H-pyran-2-yloxy)butylene-1,1-bisphosphonate 
• 184225-12-5 tetraethyl [3,3-bis(benzyloxylcarbonyl)propylideno]bisphosphonate 
• 103457-10-9 tetraethyl (1-methylenemethoxy)methylene bisphosphonate 
• 136496-82-7 ethyl 4,4-bis(diethoxyphosphoryl)-2-ethoxycarbonylbutyrate 
• 37465-31-9 1,1-bis(diethylphosphono)ethylene 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 184225-13-6 tetraethyl 3,3-bis(phosphono)propyliden bis(carboxylic acid) 

Relevant academic research and scientific papers

MULTIFUNCTIONAL CONJUGATES

The present invention provides compounds suitable for use in the treatment of conditions where it is beneficial to halt bone loss and kill cancer cells, particularly in metastases to and primary tumours in the bone and surrounding tissues. Consequently the present invention provides compounds comprising a bisphosphonate moiety linked to a phytochemical, pharmaceutical compositions thereof and methods of treatment of bone diseases and/or proliferative disorders.

PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS

The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.

PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS

The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis.

Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.

Linking bisphosphonates to the free amino groups in fluoroquinolones: Preparation of osteotropic prodrugs for the prevention of osteomyelitis

Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic administration may provide both grea

Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bis(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit.

Estrogen derivative having carriers to bone

A novel estrogen derivative represented by the formula: STR1 is useful for treating or preventing diseases caused by estrogen deficiency.

Synthesis of novel functionalized gem-bisphosphonates

Michael-type addition of carbanions to tetraethyl ethylidenebisphosphonate affords functionalized gem-bisphosphonates, which are potentially useful in the therapy of bone tissues.