1365546-06-0Relevant articles and documents
An improved scalable route to pure dronedarone hydrochloride
Hivarekar, Raghvendra R.,Deshmukh, Sanjay S.,Tripathy., Narendra K.
, p. 677 - 681 (2012/08/07)
An efficient scalable synthesis for dronedarone hydrochloride (2) via Friedel-Craft acylation of 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H) dione (12) with 4-(3-chloropropoxy) benzoic acid (13) in good yield and high purity has been developed by using Eaton's reagent instead of hazardous and toxic metal halide catalyst like AlCl3 or SnCl4.