1365620-67-2

Basic information

• Product Name: (E)-[3-(4-bromophenyl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone
• Synonyms: (E)-[3-(4-bromophenyl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone
• CAS NO: 1365620-67-2
• Molecular Weight: 342.984
• Mol File: 1365620-67-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-[3-(4-bromophenyl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-[3-(4-bromophenyl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone(1365620-67-2)
• EPA Substance Registry System: (E)-[3-(4-bromophenyl)-1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)]propenone(1365620-67-2)

Safety Data

• Hazardous Substances Data: 1365620-67-2(Hazardous Substances Data)

Upstream product

• 13815-89-9 2-bromobenzene-1,4-dicarbonyl dichloride 
• 586-35-6 2-bromo-1,4-benzenedicarboxylic acid 
• 89980-92-7 (2-bromo-1,4-phenylene) dimethyl carbinol 
• 18643-86-2 dimethyl 2-bromoterephthalate 
• 553-94-6 4-bromo-m-xylene 
• 1195621-94-3 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde 
• 99-90-1 para-bromoacetophenone 
• 947162-87-0 1,3-dihydro-1-hydroxy-6-hydroxymethyl-2,1-benzoxaborole 

Relevant articles and documents

Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents

We report the novel chalcone-benzoxaborole hybrids and their structure-activity relationship againstTrypanosoma brucei parasites. The 4-NH2 derivative 29 and 3-OMe derivative 43 were found to have excellent potency. The synergistic 4-NH2-3-OMe compound 49 showed an IC50 of 0.010 μ/mL and resulted in 100% survival and zero parasitemia in a murine infection model, which represents one of the most potent compounds discovered to date from the benzoxaborole class that inhibit T. brucei growth.