136604-50-7

Basic information

• Product Name: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide
• Synonyms: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide;2-Amino-5-(phthalimid-1ylethyl)-1,3-thiazole hydrobromide;N-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]phthalimide hydrobromide;2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide, 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]isoindolin-1,3-dione hydrobromide;2-[2-(2-amino-1,3-thiazol-5-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione hydrobromide
• CAS NO: 136604-50-7
• Molecular Formula: BrH*C₁₃H₁₁N₃O₂S
• Molecular Weight: 354.22228
• Mol File: 136604-50-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide(136604-50-7)
• EPA Substance Registry System: 2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide(136604-50-7)

Safety Data

• Hazardous Substances Data: 136604-50-7(Hazardous Substances Data)

Usage

Chemical compound

2-[2-(2-Amino-1,3-thiazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione hydrobromide

Salt form

hydrobromide

Derivative of

isoindole

Contains

thiazole ring, aminoethyl group

Physical form

white to off-white crystalline powder

Potential applications

pharmaceutical research, drug development

Caution

handle and use with proper safety protocols and regulations

Upstream product

• 136918-14-4 phthalimide 
• 85-44-9 phthalic anhydride 
• 24697-70-9 N-(4-hydroxybutyl)phthalimide 
• 133118-36-2 2-bromo-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyraldehyde 
• 17356-08-0 thiourea 
• 1074-82-4 potassium phtalimide 
• 3598-60-5 4-phthalimidobutanal 

Downstream Products

• 221658-98-6 N-2-<(2-amino-5-thiazolyl)ethyl>-3,4,5-trimethoxyphenylacetamide 
• 230310-39-1 N-2-<(2-amino-5-thiazolyl)ethyl>-3,4,5-trimethoxyphenethylamine 

Relevant articles and documents

Beta3-Adrenoreceptor agonists, agonist compositions and methods of using

The invention provides β3-adrenoreceptor agonists, pharmaceutical compositions comprising β3-adrenoreceptor agonist compounds, and methods of using such compounds for stimulating, regulating or modulating metabolism of fats in adipos

Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2- aminoethyl)thiazoles

It is well known that both histamine and dimaprit show moderate histamine H2-receptor agonistic activities on the guinea pig right atrium. Quantum chemical calculations on these two compounds showed similarities in electron distributions and molecular electrostatic potentials (MEP's), which could be extended to rigid analogues [2-amino-5-(2-aminoethyl)thiazoles] of the latter structure. On the base of these results a series of substituted 4- and 5-(2- aminoethyl)thiazoles was synthesized applying small alkyl substitution variations as reported for histamine. 2-Amino-5-(2-aminoethyl)-4- methylthiazole (Amthamine) proved to be the most potent full histamine H2- receptor agonist on the guinea pig right atrium, being with a pD2 value of 6.21 slightly more potent than histamine. This compound shows no affinity for H1-receptors and is a full but weak agonist on the histamine H3-receptor with a pD2 value of 4.70, thus showing a marked specificity for histamine H2-receptors. In the 5-(2-aminoethyl)thiazole series the presence of a 2- amino substituent proved to be not essential for stimulation of the histamine H2-receptor, leading to the important conclusion that in contrast to histamine, for this series, acceptance of a proton by the thiazole nucleus of the agonist from the active site of the receptor is sufficient for the stimulation of the histamine H2-receptor.