136663-21-3

Basic information

• Product Name: METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE
• Synonyms: METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE;BUTTPARK 121\16-98;5-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole;5-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester;Methyl 2-Methylbenzo[d]oxazole-5-carboxylate;Methyle2-methyl-1, 3-benzoxazole-5-carboxylate
• CAS NO: 136663-21-3
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Mol File: 136663-21-3.mol

Chemical Properties

• Melting Point: 66-68°C
• Boiling Point: 286.7°Cat760mmHg
• Flash Point: 127.2°C
• Appearance: White/Crystalline Powder
• Density: 1.243g/cm³
• Vapor Pressure: 0.00259mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• PKA: -2.20±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE(136663-21-3)
• EPA Substance Registry System: METHYL 2-METHYL-1,3-BENZOXAZOLE-5-CARBOXYLATE(136663-21-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 136663-21-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-methyl-1,3-benzoxazole-5-carboxylate is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential biological activities.
Used in Organic Synthesis:
Methyl 2-methyl-1,3-benzoxazole-5-carboxylate is used as a reactant in organic synthesis to form more complex compounds, contributing to the development of new chemical entities with potential applications in various fields.

InChI:InChI=1/C10H9NO3/c1-6-11-8-5-7(10(12)13-2)3-4-9(8)14-6/h3-5H,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 99-42-3 methyl (4-hydroxy-3-nitro)benzoate 
• 91-66-7 N,N-diethylaniline 
• 78-39-7 Triethyl orthoacetate 
• 64-19-7 acetic acid 
• 115-80-0 Triethyl orthopropionate 

Downstream Products

• 359446-37-0 C₁₆H₁₄N₂O₂ 
• 1048974-23-7 C₁₅H₁₁ClN₂O₂ 
• 359446-38-1 C₁₆H₁₄N₂O₃ 
• 1048974-26-0 C₁₅H₁₁N₃O₄ 
• 291299-47-3 C₁₅H₁₂N₂O₂ 
• 136663-38-2 (2-methyl-1,3-benzoxazol-5-yl)methanol 
• 90322-32-0 2-methyl-1,3-benzoxazole-5-carboxylic acid 
• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 

Relevant articles and documents

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.

Synthesis of some novel 2-substituted-N-aryl-benzoxazole-5-carboxamides using cobalt dipyridine dichloride as a catalyst

(Chemical Equation Presented) An efficient synthesis of some novel 2-substituted-N-aryl-benzoxazole-5-carboxamides from 2-substituted - 5-carbomethoxy benzoxazole on treatment with different substituted anilines promoted by cobalt dipyridine dichloride as a catalyst is described. This new approach has the advantage of excellent yields (90%) and short reaction times 1-2 h.

Novel synthesis of benzoxazoles from o-nitrophenols and amines

o-Nitrophenols and o-nitroaniline were reacted with amines at 210-215°C to produce the corresponding benzoxazoles and benzimidazoles, respectively, in moderate yields. The reactions between o-nitrophenols containing a CO2Me or OMe group on their benzene rings and N,N-diethylaniline were examined to investigate the effects of the position and electronic character of these substituents on the formation of the oxazole ring.