136669-95-9

Upstream product

• 28478-46-8 methyl 4-hydroxy-2-methoxybenzoate 
• 136669-90-4 methyl 2-hydroxy-4-(trityloxy)benzoate 
• 136669-94-8 4-{2-[[(E)-Hydroxyimino]-(4-methylsulfanyl-phenyl)-methyl]-5-methylsulfanyl-phenoxy}-butyric acid 
• 144888-64-2 4-[5-Methylsulfanyl-2-(4-methylsulfanyl-benzoyl)-phenoxy]-butyric acid methyl ester 
• 136669-93-7 4-[5-Methylsulfanyl-2-(4-methylsulfanyl-benzoyl)-phenoxy]-butyric acid 
• 136669-92-6 (2-Methoxy-4-methylsulfanyl-phenyl)-(4-methylsulfanyl-phenyl)-methanone 
• 95420-30-7 4-<(dimethylamino)thioxomethoxy>-2-methoxybenzoic acid methyl ester 
• 69883-78-9 2-methoxy-4-(methylthio)benzoyl chloride 
• 72856-73-6 2-methoxy-4-(methylsulfanyl)benzoic acid 
• 95420-72-7 4-mercapto-2-methoxybenzoic acid 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant academic research and scientific papers

Safety-catch anchoring linkage for synthesis of peptide amides by Boc/Fmoc strategy

2-Methoxy-4,4'-bis(methylthio)benhydrylamine (10) and the corresponding disulfoxide were prepared and tested as a model amide protecting groups for their stability toward acidic conditions. Subsequently, the novel 4-[4,4'-bis(methylsulfinyl)-2-oxy-(9-fluorenylmethyloxycarbonyl) benzhydrylamino]butanoic acid (SCAL) handle (9) has been prepared and applied to solid-phase peptide synthesis of C-terminal peptide amide using both 9-fluorenylmethyloxycarbonyl (Fmoc) and tert-butyloxycarbonyl (Boc) groups for N(α)-amino protection.